Exploring Strategies To Bias Sequence in Natural and Synthetic Oligomers and Polymers

Accounts of Chemical Research
Jan K SzymańskiLeroy Cronin

Abstract

Millions of years of biological evolution have driven the development of highly sophisticated molecular machinery found within living systems. These systems produce polymers such as proteins and nucleic acids with incredible fidelity and function. In nature, the precise molecular sequence is the factor that determines the function of these macromolecules. Given that the ability to precisely define sequence emerges naturally, the fact that biology achieves unprecedented control over the unit sequence of the monomers through evolved enzymatic catalysis is incredible. Indeed, the ability to engineer systems that allow polymer synthesis with precise sequence control is a feat that technology is yet to replicate in artificial synthetic systems. This is the case because, without access to evolutionary control for finely tuned biological catalysts, the inability to correct errors or harness multiple competing processes means that the prospects for digital control of polymerization have been firmly bootstrapped to biological systems or limited to stepwise synthetic protocols. In this Account, we give an overview of strategies that have been used over the last 5 years in efforts to program polymer synthesis with sequence control in the ...Continue Reading

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Citations

Sep 15, 2018·Chemistry, an Asian Journal·Stephen A HillLaura Hartmann
Mar 18, 2021·Accounts of Chemical Research·Laurence Charles, Jean-François Lutz
Sep 15, 2020·ACS Applied Materials & Interfaces·Christopher Cody WalkerErik E Santiso
Sep 20, 2018·Journal of the American Chemical Society·Zixuan HuangJiangtao Xu

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