Exploring the alternative: Fish, flies and worms as preclinical models for ALS.

Neuroscience Letters
Elke BraemsLudo Van Den Bosch

Abstract

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterized by the loss of upper and lower motor neurons. In general, patients succumb to respiratory insufficiency due to respiratory muscle weakness. Despite many promising therapeutic strategies primarily identified in rodent models, patient trials remain rather unsuccessful. There is a clear need for alternative approaches, which could provide directions towards the justified use of rodents and which increase the likelihood to identify new promising clinical candidates. In the last decades, the use of fast genetic approaches and the development of high-throughput screening platforms in the nematode Caenorhabditis elegans, in the fruit fly (Drosophila melanogaster) and in zebrafish (Danio rerio) have contributed to new insights into ALS pathomechanisms, disease modifiers and therapeutic targets. In this mini-review, we provide an overview of these alternative small animal studies, modeling the most common ALS genes and discuss the most recent preclinical discoveries. We conclude that small animal models will not replace rodent models, yet they clearly represent an important asset for preclinical studies.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J P PhillipsA J Hilliker
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E RippsJ W Gordon
Jun 10, 1998·Nature Genetics·T L ParkesG L Boulianne
Mar 24, 2000·Science·G M RubinS Lewis
Sep 3, 2005·Experimental Gerontology·Matthew D W PiperLinda Partridge
Jan 16, 2007·Journal of Neurology·Clare A JohnstonAmmar Al-Chalabi
Jul 20, 2007·Human Molecular Genetics·Robin LemmensWim Robberecht
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Erik M Jorgensen
Jul 4, 2008·The Journal of Biological Chemistry·Melanie R WatsonNancy M Bonini
Jun 30, 2009·FEBS Letters·Makiko YamashitaMasato Hasegawa
Jul 22, 2009·BMC Neuroscience·Steven D Buckingham, David B Sattelle
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yan LiJane Y Wu
Mar 4, 2010·Acta Neuropathologica·Brian C KraemerGerard D Schellenberg
Apr 20, 2010·Human Molecular Genetics·Clotilde Lagier-TourenneDon W Cleveland
May 28, 2010·Disease Models & Mechanisms·Tennore RameshChristine E Beattie
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gillian P RitsonJ Paul Taylor
Jun 5, 2010·CNS & Neurological Disorders Drug Targets·Frank Hirth
Jul 8, 2010·The EMBO Journal·Dorothee DormannChristian Haass
Jul 14, 2010·Neurobiology of Disease·Nancy R StallingsJeffrey L Elliott
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Shuo-Chien LingDon W Cleveland
Aug 12, 2010·Human Molecular Genetics·Daryl A BoscoLawrence J Hayward
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole F LiachkoBrian C Kraemer
Dec 15, 2010·Biotechnology Journal·Maria Markaki, Nektarios Tavernarakis
Mar 19, 2011·Pharmacological Reviews·Udai Bhan Pandey, Charles D Nichols
Apr 14, 2011·Human Molecular Genetics·Nicholas A LansonUdai Bhan Pandey
Aug 6, 2011·Progress in Neurobiology·Giulietta RiboldiStefania Corti

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