Exploring the antagonistic producer Streptomyces MSI051: implications of polyketide synthase gene type II and a ubiquitous defense enzyme phospholipase A2 in the host sponge Dendrilla nigra.

Current Microbiology
Joseph Selvin

Abstract

To explore the functional role of the antagonistic producer strain Streptomyces dendra sp. nov. MSI051 in the host sponge Dendrilla nigra, hypothetical factors including the antagonistic potential of MSI051 against biofilm bacteria and a ubiquitous defense enzyme phospholipase A2 (PLA2) in host sponge as well as in bacterial symbiont MSI051 were determined. The host sponge D. nigra and associated bacterial symbiont MSI051 contained high levels of PLA2. The host sponge showed PLA2 activity to the extent of 1032 U/L, with a specific activity of 2021 U/g, and strain MSI051 showed similar activity. The findings of the present study suggest that PLA2 in the sponge-associated bacteria might have an integrated functional role in the host defense system of marine sponges. This report may be the first on the role of PLA2 activity in sponge-associated bacteria. Isolate MSI051 was a potential antagonistic producer which showed a broad spectrum of antibacterial activity. Polyketide synthase gene type II in MSI051 ultimately evidenced the antagonistic potential. Antimicrobial activity was found to be positively skewed toward biofilm bacteria. This implies a functional role of MSI051 in the protection of host sponge against fouling processes.

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Citations

Nov 16, 2012·Marine Biotechnology·Francesca MussinoMarco Giovine
May 19, 2010·Marine Drugs·Tresa Remya A ThomasPonnapakkam A LokaBharathi
Jun 3, 2014·Journal of Nanobiotechnology·George Seghal KiranNaif Abdullah Al-Dhabi
Jul 6, 2014·Antonie van Leeuwenhoek·Juliana F Santos-GandelmanMarinella S Laport
Jan 22, 2010·FEMS Microbiology Reviews·Keith F ChaterHildgund Schrempf
May 6, 2016·Marine Drugs·Anak Agung Gede IndraningratDetmer Sipkema
Nov 9, 2016·Critical Reviews in Microbiology·Ganesan SathiyanarayananJoseph Selvin
Aug 23, 2020·Applied Microbiology and Biotechnology·Bruno Francesco Rodrigues de OliveiraMarinella Silva Laport

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