Exploring the arthritogenicity of Streptococcus dysgalactiae subspecies equisimilis

BMC Microbiology
Oddvar OppegaardBård Reiakvam Kittang

Abstract

During the past decades, Streptococcus dysgalactiae subspecies equisimilis (SDSE) has been increasingly recognized as an important human pathogen. Osteoarticular infections is one of the predominant disease manifestations of SDSE, but the pathogenetic rationale for its arthritogenicity has yet to be unravelled. We aimed to explore if the rising incidence of osteoarticular infections caused by this pathogen in our region emanated from clonal expansion of strains with enhanced tropism for bone and joint tissue components or orthopaedic implants. Twenty-nine SDSE-isolates associated with osteoarticular infections were retrospectively identified. Their genomic content and affinity for fibronectin, collagen and stainless steel were compared to 24 temporally and geographically matched SDSE blood culture isolates obtained from patients without bone or joint infections. Despite a thorough genetic and phenotypic dissection, neither the presence or absence of any single gene, nor the binding abilities of the SDSE isolates, were predictive of clinical entity. SNP analysis revealed a heterogenous population, and a correlation between phylogenetic relationships and disease manifestation was not evident. However, we identified a strong conco...Continue Reading

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Citations

Jan 12, 2021·Frontiers in Microbiology·Cinthia Alves-BarrocoAlexandra R Fernandes
Mar 23, 2021·Journal of Medical Microbiology·Paulina GlajznerMagdalena Szemraj

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Datasets Mentioned

BETA
KX838908
KX838909
BAN92583
SDSE167
AP012976
CP002215

Methods Mentioned

BETA
genotyping
dissection

Software Mentioned

FastQC
FastTree
SPSS PASW Statistics
RAST
Geneious
Trimmomatic
Quast
SPSS Statistics
Prokka

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