Exploring the association between Cerebral small-vessel diseases and motor symptoms in Parkinson's disease

Brain and Behavior
Ying WanZhenguo Liu


to explore the association between cerebral small-vessel diseases (CSVDs) and motor symptoms in Parkinson's disease (PD). 137 PD patients were recruited into the study. Detailed motor symptoms, including tremor, rigidity, bradykinesia, and axial impairment, were evaluated using Unified Parkinson's disease Rating Scale (UPDRS). Non-motor symptoms, including cognition, anxiety, and depression, were evaluated using Montreal Cognitive Assessment (MoCA), Hamilton anxiety scale (HAMA), and Hamilton depression scale (HAMD). Brain MRI was used to assess the subtypes of CSVDs, including lacunes, enlarged perivascular spaces (EPVS), and white matter hyperintensities (WMH). WMH were furtherly divided into deep WMH (DWMH) and periventricular hyperintensities (PVH). The association between CSVDs and motor symptoms was analyzed. Patients were divided into the postural instability and gait disability (PIGD) group and non-PIGD group. Demographic, clinical and CSVDs variables were compared between the two groups. CSVDs subtypes were all detected in the participants with different prevalence rates and severity degrees. We found a close association between EPVS in basal ganglia and the tremor score (p = 0.032), and between DWMH in the frontal and...Continue Reading


Nov 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Tatjana RundekJason Margolesky
Dec 24, 2019·Journal of Parkinson's Disease·Aaron Ben-JosephAlastair J Noyce


Jan 1, 1993·Journal of the Neurological Sciences·Philip ScheltensJ Valk
Sep 27, 2000·Brain : a Journal of Neurology·G N LewisS E Walt
May 13, 2008·Biological Psychiatry·Ki Woong KimMartha E Payne
Nov 4, 2008·Archives of Gerontology and Geriatrics·Seung-Jae LeeSo-Lyung Jung
Jan 9, 2010·Stroke; a Journal of Cerebral Circulation·Fergus N DoubalJoanna M Wardlaw
Mar 19, 2011·Nature Reviews. Neuroscience·Dwight J KravitzMortimer Mishkin
Jun 1, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·John G NuttBastiaan R Bloem
Jun 10, 2011·Brain : a Journal of Neurology·Nicolaas I BohnenRoger L Albin
May 11, 2013·Parkinsonism & Related Disorders·In-Uk SongSung-Woo Chung
Jun 13, 2014·Journal of Neurology·Jee Hyun HamPhil Hyu Lee
May 15, 2016·Neurology·Jorine F van der HeedenJacobus J van Hilten
Jun 22, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Naveed MalekPRoBaND Clinical Consortium
Jul 29, 2016·Acta Neurologica Scandinavica·N LenfeldtL Forsgren
Aug 9, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Guohua ZhangLijuan Wang
Dec 12, 2017·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Michele CavallariCharles R G Guttmann
May 5, 2018·Cardiovascular Research·Rosalind BrownJoanna M Wardlaw
Jul 25, 2018·Journal of Parkinson's Disease·Meltem CilizWalter Maetzler

Related Concepts

Unified Parkinson's Disease Rating Scale Questionnaire
Occipital Lobe
Magnetic Resonance Imaging
Hamilton Rating Scale for Depression
Structure of Perivascular Space
Clinic/Center - Developmental Disabilities

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.