Exploring the assumptions underlying genetic variation in host nematode resistance (Open Access publication).

Genetics, Selection, Evolution : GSE
Andrea Beate Doeschl-WilsonS C Bishop

Abstract

The wide range of genetic parameter estimates for production traits and nematode resistance in sheep obtained from field studies gives rise to much speculation. Using a mathematical model describing host - parasite interactions in a genetically heterogeneous lamb population, we investigated the consequence of: (i) genetic relationships between underlying growth and immunological traits on estimated genetic parameters for performance and nematode resistance, and (ii) alterations in resource allocation on these parameter estimates. Altering genetic correlations between underlying growth and immunological traits had large impacts on estimated genetic parameters for production and resistance traits. Extreme parameter values observed from field studies could only be reproduced by assuming genetic relationships between the underlying input traits. Altering preferences in the resource allocation had less pronounced effects on the genetic parameters for the same traits. Effects were stronger when allocation shifted towards growth, in which case worm burden and faecal egg counts increased and genetic correlations between these resistance traits and body weight became stronger. Our study has implications for the biological interpretation...Continue Reading

References

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Citations

Dec 28, 2010·Veterinary Parasitology·Falko KaufmannMatthias Gauly
May 11, 2011·The British Journal of Nutrition·Yan C S M LaurensonIlias Kyriazakis
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·A B Doeschl-Wilson
Aug 10, 2017·Parasite : Journal De La Société Française De Parasitologie·Felix HeckendornChris Stricker

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