Exploring the domain structure of modular nonribosomal peptide synthetases

Structure
T Weber, M A Marahiel

Abstract

Recently, considerable insight has been gained into the modular organization of nonribosomal peptide synthetases (NRPS). The three-dimensional structures of domains associated with substrate adenylation and covalent binding have been solved as well as the structure of a priming enzyme required for the post-translational modification of NRPS. Taken together, these studies will help us to understand the architecture of these mega-enzymes.

References

Mar 17, 1995·The Journal of Biological Chemistry·T Stachelhaus, M A Marahiel
Oct 20, 1995·The Journal of Biological Chemistry·R H Lambalot, C T Walsh
Jun 28, 1996·The Journal of Biological Chemistry·T SteinH R Morris
Nov 1, 1996·Chemistry & Biology·R H LambalotC T Walsh
Dec 1, 1996·Current Opinion in Structural Biology·C Engel, R Wierenga
Jun 1, 1997·Trends in Biochemical Sciences·J G Arnez, D Moras
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·J T KealeyP J Barr
Aug 26, 1998·The Journal of Biological Chemistry·T StachelhausM A Marahiel
Feb 18, 1999·Chemistry & Biology·D Konz, M A Marahiel
Jul 28, 1999·Chemistry & Biology·T StachelhausM A Marahiel
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·H D MootzM A Marahiel
Jun 30, 2000·Chemistry & Biology·S Doekel, M A Marahiel
Feb 20, 2002·Chemical Reviews·David A. Hopwood

❮ Previous
Next ❯

Citations

Jul 4, 2002·Journal of Molecular Biology·Sujun HuaZhirong Sun
Nov 14, 2002·Biochimica Et Biophysica Acta·Angel Alonso, Jennifer Reed
Feb 3, 2009·Nature Chemical Biology·Pooja AroraRajesh S Gokhale
Jul 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marko MocibobIvana Weygand-Durasevic
Sep 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jurgen J MayMilton T Stubbs
May 8, 2010·Foodborne Pathogens and Disease·Jung-Beom KimDeog-Hwan Oh
Dec 6, 2011·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Xiuhua LiuSujuan Xu
Nov 28, 2007·Applied and Environmental Microbiology·Roland J SiezenJohan E T van Hylckama Vlieg
Oct 3, 2013·Marine Drugs·Florie DesriacYannick Fleury
Feb 4, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Markus SchrettlHubertus Haas
Dec 7, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jonathan D Awaya, Jennifer L Dubois
Jul 2, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Mehdi ImaniMahboobeh Nazari
Feb 17, 2007·FEBS Letters·Uwe LinneMohamed A Marahiel
Aug 1, 2008·Expert Opinion on Drug Discovery·Nishikant V Wase, Phillip C Wright
Sep 10, 2003·Chembiochem : a European Journal of Chemical Biology·Robert FinkingMohamed A Marahiel
Mar 17, 2006·Rapid Communications in Mass Spectrometry : RCM·Mustapha Mohamed-BenkadaYves François Pouchus
Jun 16, 2006·FEMS Microbiology Reviews·Martin Welker, Hans von Döhren
Feb 26, 2015·Protein Engineering, Design & Selection : PEDS·Michael J Tarry, T Martin Schmeing
Oct 19, 2004·Annual Review of Microbiology·Robert Finking, Mohamed A Marahiel
Sep 27, 2002·Chemistry & Biology·Stephan A SieberMohamed A Marahiel
Jul 17, 2013·Current Opinion in Chemical Biology·Michio SatoKenji Watanabe
Jan 26, 2017·Chembiochem : a European Journal of Chemical Biology·Bradley J Harden, Dominique P Frueh
Aug 27, 2003·Medicinal Research Reviews·Li-June Ming
Oct 27, 2005·Angewandte Chemie·Helge B Bode, Rolf Müller
Feb 14, 2020·Organic & Biomolecular Chemistry·Sebastian Götze, Pierre Stallforth
Apr 18, 2020·Biological Reviews of the Cambridge Philosophical Society·Miguel A Naranjo-Ortiz, Toni Gabaldón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.