Exploring the effect of electrical muscle stimulation as a novel treatment of intractable tremor in Parkinson's disease

Journal of the Neurological Sciences
Onanong JitkritsadakulRoongroj Bhidayasiri

Abstract

As the pathophysiology of tremor in Parkinson disease (PD) involves a complex interaction between central and peripheral mechanisms, we propose that modulation of peripheral reflex mechanism by electrical muscle stimulation (EMS) may improve tremor temporarily. To determine the efficacy of EMS as a treatment for drug resistant tremor in PD patients. This study was a single-blinded, quasi-experimental study involving 34 PD patients with classic resting tremor as confirmed by tremor analysis. The EMS was given at 50Hz over the abductor pollicis brevis and interrosseus muscles for 10s with identified tremor parameters before and during stimulation as primary outcomes. Compared to before stimulation, we observed a significant reduction in the root mean square (RMS) of the angular velocity (p<0.001) and peak magnitude (p<0.001) of resting tremor while tremor frequency (p=0.126) and dispersion (p=0.284) remained unchanged during stimulation. The UPDRS tremor score decreased from 10.59 (SD=1.74) before stimulation to 8.85 (SD=2.19) during stimulation (p<0.001). The average percentage of improvement of the peak magnitude and RMS angular velocity was 49.57% (SD=38.89) and 43.81% (SD=33.15) respectively. 70.6% and 61.8% of patients exper...Continue Reading

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Citations

Jun 6, 2018·Frontiers in Neuroscience·Bin ZhangDingguo Zhang
Apr 20, 2017·Frontiers in Neuroscience·Jakob L DideriksenDario Farina
Feb 17, 2021·Journal of Neuroengineering and Rehabilitation·Alejandro Pascual-ValduncielJosé L Pons
Aug 27, 2021·Frontiers in Neurology·Julio S Lora-MillanEduardo Rocon
Sep 28, 2021·Frontiers in Aging Neuroscience·Onanong PhokaewvarangkulRoongroj Bhidayasiri

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