Abstract
The aquaculture industry is suffering from losses associated with bacterial infections by opportunistic pathogens. Vibrio anguillarum is one of the most important pathogens, causing vibriosis in fish and shellfish cultures leading to high mortalities and economic losses. Bacterial resistance to antibiotics and inefficient vaccination at the larval stage of fish emphasizes the need for novel approaches, and phage therapy for controlling Vibrio pathogens has gained interest in the past few years. In this study, we examined the potential of the broad-host-range phage KVP40 to control four different V. anguillarum strains in Atlantic cod (Gadus morhua L.) and turbot (Scophthalmus maximus L.) larvae. We examined larval mortality and abundance of bacteria and phages. Phage KVP40 was able to reduce and/or delay the mortality of the cod and turbot larvae challenged with V. anguillarum. However, growth of other pathogenic bacteria naturally occurring on the fish eggs prior to our experiment caused mortality of the larvae in the unchallenged control groups. Interestingly, the broad-spectrum phage KVP40 was able to reduce mortality in these groups, compared to the nonchallenge control groups not treated with phage KVP40, demonstrating tha...Continue Reading
References
Jan 1, 1992·Microbiology and Immunology·S MatsuzakiT Kawata
Jan 1, 1995·FEMS Microbiology Letters·T InoueS Tanaka
Jun 29, 1999·Microbial Ecology·G H Hansen, J A Olafsen
Aug 12, 2000·Fish & Shellfish Immunology·I R BricknellA E Ellis
Sep 9, 2004·Microbiology and Molecular Biology Reviews : MMBR·Fabiano L ThompsonJean Swings
Jun 1, 1989·Applied and Environmental Microbiology·G H Hansen, J A Olafsen
Apr 1, 1995·Applied and Environmental Microbiology·M N SkovJ L Larsen
May 13, 2008·Applied and Environmental Microbiology·Anne Rønnest StenholmMathias Middelboe
Jan 1, 2009·Current Pharmaceutical Biotechnology·Lawrence D Goodridge
Mar 30, 2010·Nature Reviews. Microbiology·Simon J LabrieSylvain Moineau
Nov 17, 2010·Fish & Shellfish Immunology·Helene MikkelsenMarit Seppola
Aug 16, 2011·Journal of Fish Diseases·I FransH Rediers
Dec 14, 2011·Marine Drugs·Carla PereiraAdelaide Almeida
Feb 7, 2012·Applied and Environmental Microbiology·Krit KhemayanTimothy W Flegel
Mar 13, 2014·Applied and Environmental Microbiology·Demeng TanMathias Middelboe
Dec 3, 2014·PloS One·Yolanda J SilvaAdelaide Almeida
Apr 26, 2015·Applied and Environmental Microbiology·Demeng TanMathias Middelboe
Jun 18, 2015·MBio·Demeng TanMathias Middelboe
Mar 8, 2016·PloS One·Panos G KalatzisPantelis Katharios
Mar 10, 2016·Perspectives in Clinical Research·Priya RanganathanRakesh Aggarwal
Aug 4, 2016·Frontiers in Microbiology·Vengadesh LetchumananLearn-Han Lee
Citations
Jan 10, 2019·FEMS Microbiology Ecology·Daniel CastilloMathias Middelboe
Oct 28, 2019·Viruses·Daniel CastilloMathias Middelboe
Jun 10, 2020·Antibiotics·Justyna D KowalskaJarosław Dastych
Jun 17, 2020·Journal of Applied Microbiology·Bernardo Veyrand-QuirósEduardo Quiroz-Guzman
Mar 3, 2018·Antibiotics·Panos G KalatzisMathias Middelboe
Jan 10, 2019·Virology Journal·Joanna KazimierczakJarosław Dastych
Oct 28, 2019·Antibiotics·Gabriel M F AlmeidaLotta-Riina Sundberg
Jul 10, 2019·Frontiers in Microbiology·Marcela LeónRoberto Bastías
Aug 14, 2020·Antibiotics·Carmen SieiroTomás G Villa
Sep 5, 2020·Antibiotics·Maciej ŻaczekAndrzej Górski
Mar 13, 2021·Applied Microbiology and Biotechnology·Bernardo Veyrand-QuirósEduardo Quiroz-Guzman
Mar 7, 2021·Applied and Environmental Microbiology·Gary P RichardsAlexander Sulakvelidze
May 6, 2021·Microorganisms·Valentina L DonatiLone Madsen
Aug 9, 2021·Current Opinion in Biotechnology·Gian Marco LunaKonstantinos Kormas
Aug 19, 2021·Applied and Environmental Microbiology·Zhenhe XuQin Liu
Dec 17, 2021·Diseases of Aquatic Organisms·Wei LinYigang Tong