Exploring the Effect of Phage Therapy in Preventing Vibrio anguillarum Infections in Cod and Turbot Larvae

Antibiotics
Nanna RørboMathias Middelboe

Abstract

The aquaculture industry is suffering from losses associated with bacterial infections by opportunistic pathogens. Vibrio anguillarum is one of the most important pathogens, causing vibriosis in fish and shellfish cultures leading to high mortalities and economic losses. Bacterial resistance to antibiotics and inefficient vaccination at the larval stage of fish emphasizes the need for novel approaches, and phage therapy for controlling Vibrio pathogens has gained interest in the past few years. In this study, we examined the potential of the broad-host-range phage KVP40 to control four different V. anguillarum strains in Atlantic cod (Gadus morhua L.) and turbot (Scophthalmus maximus L.) larvae. We examined larval mortality and abundance of bacteria and phages. Phage KVP40 was able to reduce and/or delay the mortality of the cod and turbot larvae challenged with V. anguillarum. However, growth of other pathogenic bacteria naturally occurring on the fish eggs prior to our experiment caused mortality of the larvae in the unchallenged control groups. Interestingly, the broad-spectrum phage KVP40 was able to reduce mortality in these groups, compared to the nonchallenge control groups not treated with phage KVP40, demonstrating tha...Continue Reading

References

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Aug 4, 2016·Frontiers in Microbiology·Vengadesh LetchumananLearn-Han Lee

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Citations

Jul 10, 2019·Frontiers in Microbiology·Marcela LeónRoberto Bastías
Sep 5, 2020·Antibiotics·Maciej ŻaczekAndrzej Górski
Mar 13, 2021·Applied Microbiology and Biotechnology·Bernardo Veyrand-QuirósEduardo Quiroz-Guzman
Aug 9, 2021·Current Opinion in Biotechnology·Gian Marco LunaKonstantinos Kormas

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