Exploring the effect of the apolipoprotein E (APOE) gene on executive function, working memory, and processing speed during the early recovery period following traumatic brain injury

Journal of Clinical and Experimental Neuropsychology
Christine R PadgettClive E Skilbeck

Abstract

There is evidence that the e4 allele of the apolipoprotein E (APOE) gene is detrimental to cognitive function, but results from traumatic brain injury (TBI) populations are mixed. A possible explanation is that APOEe2 carriers have routinely been incorporated into APOEe4 and non-e4 groups, despite APOEe2 being proposed to have an ameliorative effect. Our primary aim was to investigate the influence of APOEe4 on cognitive impairment during early recovery following TBI, excluding the potential confound of APOEe2 possession. A secondary objective was to explore whether APOEe4 displays more pronounced effects in moderate to severe TBI and to consider the potential postinjury protective influence of the APOEe2 allele. Participants who recently sustained a TBI (posttraumatic amnesia > 5 minutes) were assessed on measures of information processing speed, executive function, and working memory upon remission of posttraumatic amnesia. APOE genotype was determined by buccal saliva DNA extraction (APOEe4 n = 37, APOEe3 n = 92, APOEe2 n = 13). Stepwise multiple regressions were performed to compare APOEe4 carriers to APOEe3 homozygotes, with injury severity, age, and estimated premorbid IQ included in the first step. This model was found t...Continue Reading

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Citations

Sep 7, 2019·Journal of Molecular Neuroscience : MN·Hila Ben-MosheDaniel Michaelson
Apr 25, 2018·Frontiers in Immunology·Olga N Kokiko-Cochran, Jonathan P Godbout
Feb 27, 2020·Journal of the International Neuropsychological Society : JINS·Solrun SigurdardottirAnne-Kristine Schanke
Mar 12, 2021·Current Neurology and Neuroscience Reports·Alwyn GomezFrederick A Zeiler

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

COWAT

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