Exploring the ethnomycological potential of Lentinus squarrosulus Mont. through GC-MS and chemoinformatics tools

Mycology
Reena Roy DKrishnappa M

Abstract

Deciphering the ethnopharmacological importance is one of the prime steps towards understanding the indigenous traditional medicines practised over the centuries. With the advent of modern techniques, it is possible to unravel and explore the hidden ethnopharmacological benefits, comprising complex bioactive compounds of substantial health benefits and together it helps to treat the complex diseases without any side effects as seen in the case of modern synthetic drugs. In this concern, the present study aims to identify the ethnomycologically significant mycocompounds derived from the fruiting body of wild edible macrofungi, Lentinus squarrosulus that contain a vast array of compounds with notable edibility and a wide spectrum of medicinal applications. Proper authentication of mushroom taxonomy was exclusively done using macro and microscopic observations combining ITS DNA-based methods. Further, the isolate was subjected to fractionation in different solvent systems for mycochemical examination followed by GC-MS analysis. A total of 38 mycocompounds were identified through GC-MS and further subjected to in silico studies for drug-likeness, bioactivity and ADMET predictions to explore the druggability of mycocompounds. In sil...Continue Reading

References

Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Hassan Pajouhesh, George R Lenz
Feb 14, 2012·Molecular Biology Reports·Farhat Ahmadi AvinVikineswary Sabaratnam
Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Olusegun V Oyetayo
Sep 25, 2012·Journal of Ethnobiology and Ethnomedicine·Donatha Damian Tibuhwa
May 20, 2014·Journal of Microbiology & Biology Education·James RedfernJoanna Verran
Dec 1, 2004·Drug Discovery Today. Technologies·Christopher A Lipinski

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Datasets Mentioned

BETA
MH053154

Methods Mentioned

BETA
PCR

Software Mentioned

Molinspiration
Sequencher
PreADMET
Basic Local Alignment Search Tool ( BLAST )

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