Exploring the Extracellular Regulation of the Tumor Angiogenic Interaction Network Using a Systems Biology Model

Frontiers in Physiology
Ding Li, Stacey D Finley

Abstract

Tumor angiogenesis is regulated by pro- and anti-angiogenic factors. Anti-angiogenic agents target the interconnected network of angiogenic factors to inhibit neovascularization, which subsequently impedes tumor growth. Due to the complexity of this network, optimizing anti-angiogenic cancer treatments requires detailed knowledge at a systems level. In this study, we constructed a tumor tissue-based model to better understand how the angiogenic network is regulated by opposing mediators at the extracellular level. We consider the network comprised of two pro-angiogenic factors: vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF2), and two anti-angiogenic factors: thrombospondin-1 (TSP1) and platelet factor 4 (PF4). The model's prediction of angiogenic factors' distribution in tumor tissue reveals the localization of different factors and indicates the angiogenic state of the tumor. We explored how the distributions are affected by the secretion of the pro- and anti-angiogenic factors, illustrating how the angiogenic network is regulated in the extracellular space. Interestingly, we identified a counterintuitive result that the secretion of the anti-angiogenic factor PF4 can enhance pro-angiogenic ...Continue Reading

References

Nov 1, 1978·British Journal of Haematology·C N ChestermanF J Morgan
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S H Northrup, H P Erickson
Jun 23, 1995·The Journal of Biological Chemistry·S GengrinovitchG Neufeld
Aug 15, 1997·The Journal of Biological Chemistry·S E Stringer, J T Gallagher
May 3, 2002·The Journal of Biological Chemistry·Roni MamlukMichael Klagsbrun
May 13, 2003·The Journal of Biological Chemistry·Toshikazu ShibaMinako Ohshiro
Aug 30, 2003·Blood·Barbara MargosioGiulia Taraboletti
Apr 21, 2004·Biochemistry·Omar A IbrahimiRobert J Linhardt
May 11, 2004·Protein Science : a Publication of the Protein Society·Maximilian Schlosshauer, David Baker
Jul 30, 2004·Seminars in Thrombosis and Hemostasis·Andreas Bikfalvi
Feb 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Feilim Mac Gabhann, Aleksander S Popel
Aug 30, 2005·Molecular & Cellular Proteomics : MCP·Mathias UhlénFredrik Pontén
Nov 23, 2005·Oncology·Peter Carmeliet
Dec 13, 2005·The British Journal of Oral & Maxillofacial Surgery·E A BakerA J Dickenson
Jan 13, 2006·Biochimica Et Biophysica Acta·Bin RenRoya Khosravi-Far
Jan 2, 2007·PLoS Computational Biology·Feilim Mac Gabhann, Aleksander S Popel
Aug 21, 2008·BMC Systems Biology·Marianne O StefaniniAleksander S Popel
Feb 28, 2009·Nature Reviews. Drug Discovery·Andrew Beenken, Moosa Mohammadi
Apr 29, 2009·Methods in Molecular Biology·James R FaederWilliam S Hlavacek
Jun 11, 2009·Current Cancer Drug Targets·M Korc, R E Friesel
Sep 3, 2010·Progress in Molecular Biology and Translational Science·Lubor Borsig
Oct 7, 2010·The Journal of Biological Chemistry·Sukhbir KaurDavid D Roberts
Nov 10, 2010·PLoS Computational Biology·Bing ZhaoMichael Fannon
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 22, 2011·Cold Spring Harbor Perspectives in Biology·Stephane SarrazinJeffrey D Esko
Mar 10, 2012·Angiogenesis·Jon E PetersonJudah Folkman
May 29, 2012·Current Pharmaceutical Design·Markus WehlandDaniela Grimm
May 15, 2013·Journal of the National Cancer Institute·Stacey D Finley, Aleksander S Popel
Aug 10, 2013·Cancer Medicine·Hope E UronisHerbert I Hurwitz
Jan 31, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Andrea ResoviGiulia Taraboletti
Jun 3, 2014·Cell Communication and Signaling : CCS·Jitendra KanodiaBirgit Schoeberl

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Citations

Jul 19, 2020·Cell Communication and Signaling : CCS·Min Song, Stacey D Finley
May 3, 2020·Journal of Clinical Medicine·Qianhui Wu, Stacey D Finley

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