Exploring the Immunomodulatory Moonlighting Activities of Acute Phase Proteins for Tolerogenic Dendritic Cell Generation

Frontiers in Immunology
Inmaculada SerranoJosep M Aran

Abstract

The acute phase response is generated by an overwhelming immune-inflammatory process against infection or tissue damage, and represents the initial response of the organism in an attempt to return to homeostasis. It is mediated by acute phase proteins (APPs), an assortment of highly conserved plasma reactants of seemingly different functions that, however, share a common protective role from injury. Recent studies have suggested a crosstalk between several APPs and the mononuclear phagocyte system (MPS) in the resolution of inflammation, to restore tissue integrity and function. In fact, monocyte-derived dendritic cells (Mo-DCs), an integral component of the MPS, play a fundamental role both in the regulation of antigen-specific adaptive responses and in the development of immunologic memory and tolerance, particularly in inflammatory settings. Due to their high plasticity, Mo-DCs can be modeled in vitro toward a tolerogenic phenotype for the treatment of aberrant immune-inflammatory conditions such as autoimmune diseases and allotransplantation, with the phenotypic outcome of these cells depending on the immunomodulatory agent employed. Yet, recent immunotherapy trials have emphasized the drawbacks and challenges facing tolero...Continue Reading

References

Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Jan 1, 1989·Advances in Immunology·C A Dinarello
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Aug 29, 2000·Journal of Dermatological Science·Y XieJ W Streilein
Mar 30, 2001·Periodontology 2000·J L Ebersole, D Cappelli
May 15, 2001·International Journal of Cancer. Journal International Du Cancer·C P GrayP Hersey
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A FamilianC E Hack
Aug 15, 2001·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·R Syme, S Glück
Sep 19, 2001·The Journal of Experimental Medicine·D HawigerM C Nussenzweig
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jeremy H Brock
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Camie W Y ChanGary A Levy
May 3, 2003·Annals of the New York Academy of Sciences·Jacques BanchereauA Karolina Palucka
Mar 24, 2004·Seminars in Immunology·Luciano AdoriniGiuseppe Penna
Apr 10, 2004·Molecular Immunology·Anna M BlomBjörn Dahlbäck
Sep 11, 2004·Biochemical and Biophysical Research Communications·Sabina JanciauskieneTim Stevens
Mar 15, 2005·American Journal of Respiratory Cell and Molecular Biology·Brice KorkmazFrancis L Gauthier
Aug 11, 2005·Scandinavian Journal of Immunology·C-Q XiaM J Clare-Salzler
Sep 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alejo ChornyMario Delgado
Sep 13, 2005·Immunology Letters·Z Tobiásová-CzetoováP Pisa
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen N WaggonerYoung S Hahn
Jun 1, 2006·Blood·Chandrabala ShahJohn G Raynes
Jun 21, 2006·Scandinavian Journal of Immunology·S L Macdonald, D C Kilpatrick
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuk Yuen LanAngus W Thomson
Apr 4, 2007·Trends in Immunology·Annalisa MacagnoFederica Sallusto
Apr 24, 2007·The International Journal of Biochemistry & Cell Biology·Izabela M NitaSabina M Janciauskiene
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heth R TurnquistAngus W Thomson
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonie M van DuivenvoordeRené E M Toes
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuekang XuMichael H Kershaw
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Itay ShalevGary Levy
Jan 26, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Emily A Van VréJohan M Bosmans
Apr 24, 2008·Journal of Leukocyte Biology·Amy E AndersonCatharien M U Hilkens
Apr 26, 2008·Journal of Leukocyte Biology·Kristin M HuntoonHeinz Baumann
Jul 11, 2008·Seminars in Arthritis and Rheumatism·Oscar-Danilo Ortega-HernandezJuan-Manuel Anaya
Aug 5, 2008·Biochimica Et Biophysica Acta·Eugene D Weinberg
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eli C LewisCharles A Dinarello
Nov 11, 2008·European Journal of Immunology·Hao LiuGary A Levy

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Citations

Feb 8, 2019·Current Pharmaceutical Biotechnology·Asuka KumagaiTomo Yonezawa
May 3, 2019·Nature Reviews. Immunology·Edimara S ReisJohn D Lambris
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Truc Thi Huong DinhPatcharee Ritprajak
Aug 14, 2021·Journal of Mammalogy·Maquel E BrandimartiCatherine A Herbert

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