Oct 16, 2010

Exploring the impact of ketamine on the experience of illusory body ownership

Biological Psychiatry
Hannah L MorganPaul C Fletcher

Abstract

Our sense of body ownership is profound and familiar, yet it may be misleading. In the rubber-hand illusion, synchronous tactile and visual stimulation lead to the experience that a rubber hand is actually one's own. This illusion is stronger in schizophrenia. Given the evidence that ketamine, a noncompetitive N-methyl-D-aspartate antagonist reproduces symptoms of schizophrenia, we sought to determine whether the rubber-hand illusion is augmented by ketamine. We studied 15 healthy volunteers in a within-subjects placebo-controlled study. All volunteers carried out two versions of the rubber-hand task, each under both placebo and ketamine infusions. In one task, they saw a rubber hand being stroked in synchrony with tactile stimulation of their real, hidden hand. In the other, stroking of the real and rubber hands was asynchronous. We recorded subjective changes in sense of ownership, as well as participants' ability to localize their hidden hand. Ketamine was associated with significant increases in subjective measures of the illusion and in hand mislocalization. Although asynchronous visuotactile stimulation attenuates the strength of the illusion during both placebo and ketamine, there remained a significant illusory effect d...Continue Reading

  • References34
  • Citations41

References

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Establishment and Maintenance of Localization
Personality Assessment
Schizophrenia
Antagonist Muscle Action
Visual Perception
N-Methylaspartate
Illusions, Visual
Biologic Preservation
Psychiatry Specialty

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