Exploring the interactions between model proteins and Pd(ii) or Pt(ii) compounds bearing charged N,N-pyridylbenzimidazole bidentate ligands by X-ray crystallography

Dalton Transactions : an International Journal of Inorganic Chemistry
Giarita FerraroAntonello Merlino

Abstract

Pd(ii) and Pt(ii) compounds bearing N,N-pyridylbenzimidazole derivatives with an alkylated sulfonate or phosphonium side chain are able to bind the model protein lysozyme both covalently and non-covalently as an entire compound or as a product of a hydrolysis reaction. The interactions with the protein and the origin of the different behaviors of these complexes were unknown hitherto. Here, we present four crystal structures of their adducts with lysozyme. Pt- and Pd-containing fragments bind the protein with different stoichiometries close to the side chains of His15, Asp87, Asp101 and Asn77. The compounds bearing a phosphonium side chain degrade during the reaction with lysozyme. Data show the origin of the non-covalent mode of binding of Pd and Pt compounds bearing a sulfonate side chain, which drives the recognition process by forming a series of H-bonds and coulombic interactions with positively charged residue side chains. In a separate experiment, the structure of the adduct that is formed when the Pd(ii) compound containing an alkylated sulfonate group reacts with ribonuclease A was also determined. In this structure, the sulfonate-Pd(ii) complex binds the side chain of His105 on the surface of the protein and the side ...Continue Reading

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Citations

Mar 20, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Ahmed M Mansour, Krzysztof Radacki
Sep 7, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Giarita FerraroAntonello Merlino
Jan 20, 2021·Chemical Communications : Chem Comm·Antonello Merlino
Jun 25, 2020·Current Topics in Medicinal Chemistry·Giarita FerraroAntonello Merlino
Aug 3, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Ahmed M MansourOla R Shehab

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