Exploring the Link between the Components of Metabolic Syndrome and the Risk of Depression

BioMed Research International
Fang-Yih LiawWei-Liang Chen

Abstract

Background. Metabolic syndrome (MetS) has been reported with an increased risk of depression. MetS was also associated with insulin resistance. This study aimed to evaluate whether MetS components might contribute to depression in participants with insulin resistance (IR) or not. Methods. This study included 3,331 participants ≥18 years in the NHANES 2009-2010. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). MetS components were measured using blood chemistry and body measurements. IR was identified using the homeostasis model assessment method. Results. Predicted PHQ-9 scores significantly increased as the number of MetS components increased in patients with IR. The adjusted β coefficients of the predicted PHQ-9 score with 2, 4, and 5 MetS components were 1.803, 2.081, and 3.048, respectively (P for trend < 0.05). Low HDL-C levels were significantly associated with higher predicted total PHQ-9 scores in fully adjusted models in the IR group (P < 0.05). Conclusion. The results indicated that the presence of a greater number of components of MetS was significantly associated with higher predicted total PHQ-9 scores in participants with IR. Among the components of MetS, the most apparent associ...Continue Reading

References

Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R NosadiniF Belloni
Mar 1, 1982·The American Journal of Psychiatry·S D TargumS M Byrnes
Jul 1, 1996·QJM : Monthly Journal of the Association of Physicians·W F Kelly
Feb 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P MaheuxJ L Chiasson
Feb 19, 1999·Psychosomatic Medicine·L R WulsinV E Wells
Sep 22, 2001·Brain, Behavior, and Immunity·E P ZorrillaK Schmidt
Oct 24, 2001·Circulation·R M CarneyK E Freedland
Oct 18, 2002·Journal of Clinical Epidemiology·Beatrice A GolombSarnoff A Mednick
Dec 13, 2003·BMJ : British Medical Journal·Debbie A LawlorUNKNOWN British Women's Heart and Health Study
Jan 7, 2004·Biological Psychiatry·E Sherwood BrownBruce S McEwen
May 26, 2004·Endocrinology and Metabolism Clinics of North America·Adrian J CameronPaul Z Zimmet
Jun 25, 2005·Circulation Research·Gary F Lewis, Daniel J Rader
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Dec 21, 2011·European Archives of Psychiatry and Clinical Neuroscience·Kai G KahlSusanne Moebus
May 25, 2012·International Journal of Nursing Practice·Se Won Kang, Ji Soo Yoo
Sep 4, 2013·Molecular Psychiatry·O P AlmeidaL Flicker
Nov 6, 2014·Revista brasileira de cirurgia cardiovascular : órgão oficial da Sociedade Brasileira de Cirurgia Cardiovascular·Ebuzer Aydin, Mehmet Ozkokeli

❮ Previous
Next ❯

Citations

Mar 28, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Victoria M LimonStefan A Czerwinski
May 18, 2018·Journal of Affective Disorders·Nikolena RepousiStefanos Tyrovolas

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.