Exploring the longitudinal dynamics of herd BVD antibody test results using model-based clustering

Scientific Reports
J I EzeG J Gunn

Abstract

Determining the Bovine Viral Diarrhoea (BVD) infection status of cattle herds is a challenge for control and eradication schemes. Given the changing dynamics of BVD  virus (BVDV) antibody responses in cattle, classifying herds based on longitudinal changes in the results of BVDV antibody tests could offer a novel, complementary approach to categorising herds that is less likely than the present system to result in a herd's status changing from year to year, as it is more likely to capture the true exposure dynamics of the farms. This paper describes the dynamics of BVDV antibody test values (measured as percentage positivity (PP)) obtained from 15,500 bovines between 2007 and 2010 from thirty nine cattle herds located in Scotland and Northern England. It explores approaches of classifying herds based on trend, magnitude and shape of their antibody PP trajectories and investigates the epidemiological similarities between farms within the same cluster. Gaussian mixture models were used for the magnitude and shape clustering. Epidemiologically meaningful clusters were obtained. Farm cluster membership depends on clustering approach used. Moderate concordance was found between the shape and magnitude clusters. These methods hold po...Continue Reading

References

Oct 26, 2005·Preventive Veterinary Medicine·G J GunnA W Stott
Nov 29, 2008·BMC Bioinformatics·Marcilio C P de SoutoAlexander Schliep
Jul 28, 2009·Journal of Bioinformatics and Computational Biology·Xin Chen
Oct 28, 2014·Translational Cancer Research·Devin C KoestlerE Andres Houseman

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA

Software Mentioned

Longclust
R

Related Concepts