Exploring the mast cell enigma: a personal reflection of what remains to be done

Experimental Dermatology
B M Henz

Abstract

Mast cells are traditionally viewed as effector cells of allergic reactions and parasitic diseases, but their importance in host defense against bacteria, in tissue remodelling, their bone marrow and stem cell origin and a central role of the stem cell factor (SCF) as mast cell growth and chemotactic factor has been worked out only in recent years. Despite this, major aspects about the nature of the cells and their role in disease remain unclear. This holds in particular for the identification of mast cell precursors and the role of growth factors that stimulate specific mast cell commitment from stem cells, such as nerve growth factor, neutrotrophin-3 and certain interleukins, alone and during interaction with SCF. Early data suggesting also an involvement of specific transcription factors need to be expanded in this process. Furthermore, although mast cell proliferative disease (mastocytosis) has been shown to be often associated with SCF receptor c-kit mutations, reasons for the development of this disease remain unclear. This holds also for mast cell release mechanisms in many types of mast cell-dependent urticaria. Exciting new insights are emerging regarding the role of mast cells in bacterial infections, in defense again...Continue Reading

References

Oct 1, 1986·Journal of the American Academy of Dermatology·B M CzarnetzkiH Traupe
Jan 1, 1980·Immunobiology·B M CzarnetzkiH Niedorf
Jan 1, 1982·International Archives of Allergy and Applied Immunology·B M Czarnetzki
Jan 1, 1983·International Archives of Allergy and Applied Immunology·B M CzarnetzkiW Sterry
Jan 1, 1994·Archives of Dermatological Research·K HamannB M Czarnetzki
Jan 1, 1994·Archives of Dermatological Research·J GrabbeB M Czarnetzki
May 1, 1995·International Archives of Allergy and Immunology·P WelkerB M Czarnetzki
Jan 1, 1995·International Journal of Dermatology·S WeberB M Czarnetzki
Sep 1, 1993·The American Journal of the Medical Sciences·Y KitamuraH Matsuda
Aug 1, 1995·Experimental Dermatology·B M CzarnetzkiT Zuberbier
Aug 1, 1995·Experimental Dermatology·D D MetcalfeM Rottem
Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D BrancaccioM Gallieni
Feb 11, 1998·The Journal of Investigative Dermatology·B M Henz
May 4, 1999·International Archives of Allergy and Immunology·P WelkerB M Henz
Jan 5, 2000·The Journal of Investigative Dermatology·B HermesB M Henz
Feb 13, 2001·Experimental Dermatology·B M HenzM Babina
Feb 15, 2001·The Journal of Allergy and Clinical Immunology·H TachimotoB S Bochner
Apr 12, 2001·The British Journal of Dermatology·K Hartmann, B M Henz
Jul 12, 2001·The Journal of Allergy and Clinical Immunology·B RoyerM Arock
Nov 7, 2001·The Journal of Experimental Medicine·M F GurishK F Austen
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Torsten ZuberbierBeate M Henz
Mar 28, 2002·Leukemia Research·Karin Hartmann, Beate M Henz
May 10, 2003·Blood·Tadashi KumamotoAkira Takashima
Aug 26, 2003·The American Journal of Pathology·Karin HartmannBeate M Henz
Aug 1, 1954·The Journal of Experimental Medicine·D W FAWCETT
Sep 26, 2003·Journal of Hypertension·Naotaka ShiotaKen A Lindstedt
Sep 27, 2003·The British Journal of Dermatology·K HartmannB M Henz
Nov 6, 2003·Microscopy Research and Technique·Gabriella Chieffi BaccariRossella Monteforte
Jan 15, 2004·Experimental Dermatology·M MaurerS Galli
Dec 29, 2004·Leukemia & Lymphoma·Peter ValentDean D Metcalfe

❮ Previous
Next ❯

Citations

Oct 5, 2010·Journal of Molecular Histology·Caliandra Pinto AraújoJean Nunes dos Santos
Oct 11, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joon-Seok ChoiJin Woo Choi
Apr 22, 2009·Experimental Dermatology·Manfred Kneilling, Martin Röcken
Jul 23, 2008·Experimental Dermatology·Martin MetzMarcus Maurer
Jan 9, 2009·European Journal of Immunology·Michael A Beaven
Apr 23, 2010·International Wound Journal·Michael F Y Ng
Jun 29, 2012·The Biochemical Journal·Katja Branitzki-HeinemannMaren Von Köckritz-Blickwede
Oct 18, 2016·The Journal of Allergy and Clinical Immunology·Zhenping WangAnna Di Nardo
Mar 9, 2017·PloS One·Elaine Zayas Marcelino da SilvaConstance Oliver
Feb 1, 2012·Advances in Wound Care·Carole A Oskeritzian
Jan 30, 2008·European Journal of Immunology·Silvia Bulfone-Paus, Ralf Paus
Aug 12, 2009·Anais Brasileiros De Dermatologia·Luciana Cirillo MalufCarlos D Aparecida Dos Santos Machado Filho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.