Exploring the molecular pathogenesis associated with T-cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis

Oncology Letters
Zhangzhen ShiHongjun Li


As a rare hematological malignancy, T-cell prolymphocytic leukemia (T-PLL) has a high mortality rate. However, the comprehensive mechanisms of the underlying pathogenesis of T-PLL are unknown. The purpose of the present study was to investigate the pathogenesis of T-PLL based on a comprehensive bioinformatics analysis. The differentially expressed genes (DEGs) between T-PLL blood cell samples and normal peripheral blood cell samples were investigated using the GSE5788 Affymetrix microarray data from the Gene Expression Omnibus database. To investigate the functional changes associated with tumor progression, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were used on the identified DEGs, followed by protein-protein interaction (PPI) and sub-PPI analysis. Transcription factors and tumor-associated genes (TAGs) were investigated further. The results identified 84 upregulated genes and 354 downregulated genes in T-PLL samples when compared with healthy samples. These DEGs featured in various functions including cell death and various pathways including apoptosis. The functional analysis of DEGs revealed 17 dysregulated transcription factors and 37 dysregulated TAGs. Furthermore, the PPI netwo...Continue Reading


Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Nov 9, 2007·Leukemia & Lymphoma·Fulya OzpuyanSerhan Alkan
Apr 25, 2008·Journal of Clinical and Experimental Hematopathology : JCEH·Jia WangFusayoshi Murata
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Sep 26, 2009·Clinical Lymphoma & Myeloma·Claire E Dearden
Mar 2, 2010·Bioinformatics·Daniela BeisserMarcus T Dittrich
Dec 23, 2011·International Journal of Hematology·Akihiko YokohamaNorifumi Tsukamoto
Oct 16, 2012·Nucleic Acids Research·Min ZhaoZhongming Zhao
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
May 7, 2013·BMJ Case Reports·Abhirami VivekanandarajahShilpi Gupta
Jan 22, 2014·Genes, Chromosomes & Cancer·Anke K BergmannReiner Siebert
Apr 4, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Peng LiTao Hao
Jun 17, 2014·Gene·Jonnathan Guadalupe Santillán-BenítezJuan Manuel González-Bañales
Aug 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Robert W Tell, Curt M Horvath
Nov 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie LiuLiou Han
Dec 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu-Jun LiuZong-Ming Lin
Dec 9, 2014·Nature Medicine·Renata GrozovskyKarin M Hoffmeister

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis