Exploring the physiological correlates of chronic mild traumatic brain injury symptoms

NeuroImage. Clinical
Serguei V AstafievMaurizio Corbetta

Abstract

We report on the results of a multimodal imaging study involving behavioral assessments, evoked and resting-state BOLD fMRI, and DTI in chronic mTBI subjects. We found that larger task-evoked BOLD activity in the MT+/LO region in extra-striate visual cortex correlated with mTBI and PTSD symptoms, especially light sensitivity. Moreover, higher FA values near the left optic radiation (OR) were associated with both light sensitivity and higher BOLD activity in the MT+/LO region. The MT+/LO region was localized as a region of abnormal functional connectivity with central white matter regions previously found to have abnormal physiological signals during visual eye movement tracking (Astafiev et al., 2015). We conclude that mTBI symptoms and light sensitivity may be related to excessive responsiveness of visual cortex to sensory stimuli. This abnormal sensitivity may be related to chronic remodeling of white matter visual pathways acutely injured.

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Citations

Jul 21, 2017·Journal of Neurotrauma·Aishwarya RajeshArthur F Kramer
Aug 21, 2019·Frontiers in Systems Neuroscience·Praveen KulkarniCraig F Ferris
Oct 15, 2019·International Journal of Methods in Psychiatric Research·Erin D BiglerElisabeth A Wilde
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Mar 16, 2021·Neuropsychology Review·Hannah M LindseyTricia L Merkley
Oct 13, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Melisa GumusMaria Carmela Tartaglia

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