Exploring the Potential Antidepressant Mechanisms of TNFα Antagonists

Frontiers in Neuroscience
Kyle BrymerLisa E Kalynchuk

Abstract

Human and animal studies suggest an intriguing relationship between the immune system and the development of depression. Some peripherally produced cytokines, such as TNF-α, can cross the blood brain barrier and result in activation of brain microglia which produces additional TNF-α and fosters a cascade of events including decreases in markers of synaptic plasticity and increases in neurodegenerative events. This is exemplified by preclinical studies, which show that peripheral administration of pro-inflammatory cytokines can elicit depression-like behavior. Importantly, this depression-like behavior can be ameliorated by anti-cytokine therapies. Work in our laboratory suggests that TNF-α is particularly important for the development of a depressive phenotype and that TNF-α antagonists might have promise as novel antidepressant drugs. Future research should examine rates of inflammation at baseline in depressed patients and whether anti-inflammatory agents could be included as part of the treatment regimen for depressive disorders.

References

Jun 3, 1998·Scientific American·C B Nemeroff
Mar 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·M E ThaseR L Rudolph
May 16, 2001·Archives of General Psychiatry·A ReichenbergT Pollmächer
Apr 5, 2002·Neuron·Eric J NestlerLisa M Monteggia
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Gunter Kenis, Michael Maes
Jun 29, 2005·Pharmacology, Biochemistry, and Behavior·Adrian J Dunn, Artur H Swiergiel
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacek JaworskiMorgan Sheng
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Steven M KerfootMark G Swain
Jul 18, 2006·Neurobiology of Disease·Sabine ChourbajiPeter Gass
May 21, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Joel M GelfandSeth R Stevens
Oct 18, 2008·Journal of Neuroinflammation·Melissa K McCoy, Malú G Tansey
Apr 25, 2009·Immunology and Allergy Clinics of North America·Robert Dantzer
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Nicole DellaGioia, Jonas Hannestad
Jan 7, 2010·JAMA : the Journal of the American Medical Association·Jay C FournierJan Fawcett
Sep 30, 2010·Nature Neuroscience·Eric J Nestler, Steven E Hyman
Jul 21, 2011·Mediators of Inflammation·Hongliang ZhangJiang Wu
Sep 13, 2011·Journal of Psychiatric Research·Ghanshyam N PandeyYogesh Dwivedi
Jan 3, 2012·International Journal of Clinical Rheumatology·Mary MargarettenEdward Yelin
Aug 3, 2012·The American Journal of Psychiatry·Cristina CusinMaurizio Fava
Aug 31, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catia M TeixeiraEduardo Soriano
Oct 9, 2012·Science·Amelia J Eisch, David Petrik
Jan 17, 2013·Translational Psychiatry·A Mateus-PinheiroN Sousa
Jun 19, 2013·Neuropharmacology·Horia Pribiag, David Stellwagen

❮ Previous
Next ❯

Citations

Nov 9, 2019·Behavioural Pharmacology·Lais S RodriguesMarcelo M S Lima
Jan 12, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyle J BrymerLisa E Kalynchuk
Jul 30, 2020·Clinical Psychological Science : a Journal of the Association for Psychological Science·Daniel P MoriarityLauren B Alloy
Feb 14, 2021·Journal of Personalized Medicine·Suhyuk Chi, Moon-Soo Lee
Jul 21, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N P Komysheva, G T Shishkina

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here