Exploring the Potential of Nanotherapeutics in Targeting Tumor Microenvironment for Cancer Therapy

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Eameema MuntimaduguWahid Khan

Abstract

Advanced research in the field of cancer biology clearly demonstrated the key role of tumor microenvironment (TME) in cancer development and metastasis particularly in solid tumors. Components of TME, being non-neoplastic in nature provide supportive and permissive conditions for the growth of cancer cells. Hence it is important to modify TME in cancer therapy and this would be achieved by better understanding of TME morphological features and functioning of stromal components. Nanotechnology based drug delivery offers various advantages such as prolonged circulation time, delivery of cargo at desired site, improved bioavailability, reduced toxicity etc. over conventional chemotherapeutics. Abnormal characteristic features of TME play a paradoxical role in nanoparticulate drug delivery. Leaky vasculature, acidic and hypoxic conditions of TME helps in the accumulation of tailored nanoparticles whereas high interstitial pressure and dense stroma restrict the extravasation, homogenous distribution of nanocarriers in TME. This review mainly discusses the potential of nanotherapeutics in targeting TME by briefly discussing stromal components, therapeutic opportunities and barriers offered by TME for nanoparticulate drug delivery. Up...Continue Reading

References

Dec 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V RoyUNKNOWN North Central Cancer Treatment Group
Jun 30, 2011·Advances in Experimental Medicine and Biology·Domenico Ribatti, Enrico Crivellato
Nov 22, 2011·Cancer Metastasis Reviews·Paolo Cirri, Paola Chiarugi

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Citations

Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guangsheng CaiYulin Zhou
Nov 30, 2019·The Analyst·Huili LiAjun Wan
Nov 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Meihua ChenJinyi Lang
Feb 23, 2018·Journal of Nanobiotechnology·Christophe AlricEmilie Allard-Vannier
Apr 3, 2019·Pharmaceutics·Nagavendra KommineniWahid Khan
Nov 16, 2018·Frontiers in Pharmacology·Clara FernandesMayur C Yergeri
Oct 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xi WangLesheng Teng
Apr 8, 2020·International Journal of Nanomedicine·Ji WangJunjie Deng
Oct 17, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cherie Ann Kruger, Heidi Abrahamse
Dec 21, 2018·Current Cancer Drug Targets·Bo-Shen GongZhen-Zhen Yao
Feb 8, 2021·Journal of Cancer Research and Clinical Oncology·Lanxin JiangRunwei Yan
Mar 20, 2021·Macromolecular Bioscience·Asim MushtaqLisbeth Grøndahl
Jun 13, 2021·Macromolecular Bioscience·Hui Wen Yong, Ashok Kakkar
Sep 3, 2021·International Journal of Nanomedicine·Lu TangZihao Cai

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