Exploring the Promise of Targeting Ubiquitin-Proteasome System to Combat Alzheimer's Disease.

Neurotoxicity Research
Abdullah Al MamunGhulam Md Ashraf

Abstract

The ubiquitin (Ub)-proteasome system (UPS) is considered as a central protein degradation system in all eukaryotes. The UPS comprises of several factors such as Ub and Ub-like molecules, Ub hydrolases, E3 Ub ligases, and the proteasome itself. Numerous studies have demonstrated that the dysfunction of UPS plays an essential role in the pathogenesis and progression of Alzheimer's disease (AD). Furthermore, current evidence has suggested that the UPS components can be connected with the initial stage of AD that is characterized by synaptic dysfunction, and to the late phases of AD, marked by neurodegeneration. In AD patients, the accumulations of insoluble protein in the brain can be caused by overload or dysfunction of the UPS, or by conformational alterations in the protein substrates that prevent their degradation and recognition by the UPS. Synaptic dysfunction is also caused by defective proteolysis that has found in the initial stage in AD as the UPS is widely recognized to play a pivotal role in the regular activities of synapses. Conversely, its precise cause and pathogenesis are unclear. Presently accepted medicines for AD give symptomatic relief, though they are unable to stop the progression of the disease. Besides, th...Continue Reading

References

Oct 7, 1994·Cell·A Ciechanover
Apr 25, 1997·The Journal of Biological Chemistry·T W KimR E Tanzi
Apr 8, 1998·Annual Review of Neuroscience·D L Price, S S Sisodia
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Dec 19, 1998·The EMBO Journal·A Ciechanover
Dec 29, 1998·The Journal of Cell Biology·J A JohnstonR R Kopito
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y A LamR Layfield
Sep 6, 2002·Journal of Alzheimer's Disease : JAD·Ralph A. NixonAnne M. Cataldo
Sep 17, 2002·Experimental and Molecular Pathology·Fawzia Bardag-GorceSamuel William French
Apr 10, 2003·Free Radical Biology & Medicine·Jung-Hee Jang, Young-Joon Surh
Oct 7, 2003·Molecular Cell·Sungmin SongYong-Keun Jung
Nov 19, 2003·Gerontology·Egemen SavaskanFranz Müller-Spahn
Feb 22, 2005·The Journal of Biological Chemistry·Angelo DemuroCharles G Glabe
Sep 16, 2005·The Journal of Biological Chemistry·Philippe MarambaudPeter Davies
Nov 25, 2005·Current Pharmaceutical Design·Sudarshan C Upadhya, Ashok N Hegde
Apr 6, 2006·Journal of Biosciences·Dipankar NandiDilip Chandu
Jun 2, 2006·Journal of the American Society of Nephrology : JASN·Stewart H LeckerWilliam E Mitch
Oct 24, 2007·The Journal of Biological Chemistry·Evan ElliottIrith Ginzburg
Feb 16, 2008·Science·William E BalchJeffery W Kelly
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Xuechao Gao, Hongyu Hu
Aug 20, 2008·The Journal of Cell Biology·Sungmin SongYong-Keun Jung
Oct 7, 2008·Annual Review of Pharmacology and Toxicology·Alan L Schwartz, Aaron Ciechanover
Jan 1, 2008·Annals of Indian Academy of Neurology·Shrikant Mishra, Kalpana Palanivelu
Dec 31, 2009·FEBS Letters·Viktor I KorolchukDavid C Rubinsztein
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masayuki KanekoYasuyuki Nomura
Jul 8, 2010·Journal of Pharmacological Sciences·Ryo SaitoYasuyuki Nomura
Nov 9, 2010·Progress in Neurobiology·Antero SalminenHilkka Soininen
Mar 4, 2011·The Journal of Biological Chemistry·Umesh K JinwalChad A Dickey
Aug 27, 2011·Experimental Neurology·Daniela NecchiElda Scherini
Jan 4, 2012·Journal of Neurochemistry·Mingming ZhangWeihong Song
Mar 1, 2012·Molecular Neurobiology·Tobias MoraweChristian Behl
Jul 31, 2012·Advances in Pharmacology·Rachel F LaneHoward M Fillit
Aug 8, 2012·Biochimica Et Biophysica Acta·Valentina CecariniAnna Maria Eleuteri

❮ Previous
Next ❯

Citations

Apr 24, 2020·Current Topics in Medicinal Chemistry·Md Tanvir KabirGhulam Md Ashraf
Jun 20, 2020·Neurotoxicity Research·Md Tanvir KabirMohamed M Abdel-Daim
May 16, 2020·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim
Aug 23, 2020·International Journal of Molecular Sciences·Md Sahab UddinMohamed M Abdel-Daim
Mar 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Md Sahab UddinLotfi Aleya
May 21, 2020·Molecular Neurobiology·Md Sahab UddinGhulam Md Ashraf
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Abdullah Al MamunMohamed M Abdel-Daim
Sep 17, 2020·Molecular Neurobiology·Md Sahab UddinMohamed M Abdel-Daim
Aug 21, 2020·Neurotoxicity Research·Md Sahab UddinGhulam Md Ashraf
Nov 1, 2020·International Journal of Molecular Sciences·Sudip Dhakal, Ian Macreadie
Jun 20, 2020·Current Topics in Medicinal Chemistry·Md Tanvir KabirMohamed M Abdel-Daim
Apr 22, 2020·Brain Research Bulletin·Seetha HarilalBijo Mathew
Jun 20, 2020·Journal of the Neurological Sciences·Md Sahab UddinGhulam Md Ashraf
Mar 30, 2021·Ageing Research Reviews·Rohan GuptaPravir Kumar
Jun 2, 2020·Current Topics in Medicinal Chemistry·Md Sahab UddinGhulam Md Ashraf
Jul 10, 2021·Oxidative Medicine and Cellular Longevity·Md Sahab UddinMohamed M Abdel-Daim

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.