Exploring the pulvinar path to visual cortex.

Progress in Brain Research
Rebecca A Berman, Robert H Wurtz

Abstract

The primary pathway for visual signals from the retina to cerebral cortex is through the lateral geniculate nucleus of the thalamus to primary visual cortex. A second visual pathway has been postulated to pass through the thalamic pulvinar nucleus and to project to multiple regions of visual cortex. We have explored this second visual pathway using a method that allows us to identify the inputs and outputs of pulvinar neurons. Specifically, we applied microstimulation in the superficial layers of superior colliculus (SC) to test for orthodromic activation of pulvinar neurons receiving input from SC. We also microstimulated the cortical motion area MT and tested for antidromic activation of pulvinar to identify neurons projecting to MT (and to determine the presence of orthodromic input back to pulvinar). In this initial report, we concentrate on two observations. First, we find that there are clusters of neurons in the pulvinar that receive input from SC along with neurons that project to MT or receive input from MT. Second, we find that neurons with input from SC have characteristics of the SC superficial layers: they respond to visual stimuli but do not discharge before saccadic eye movements. Neurons projecting to MT respond...Continue Reading

References

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Citations

Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Charles C Lee, S Murray Sherman
Jan 19, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W Pieter Medendorp
Jan 19, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert H WurtzRebecca A Berman
Jan 16, 2009·Journal of Neurophysiology·J Patrick Mayo
Dec 30, 2010·Psychological Science·Miriam SperingMarisa Carrasco
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca A Berman, Robert H Wurtz
Jan 1, 2010·Advances in Cognitive Psychology·Luís M Augusto
May 15, 2013·Nature Neuroscience·Yutaka KomuraAki Miyamoto
Jun 8, 2011·The European Journal of Neuroscience·W Pieter MedendorpFrank T M Leoné
May 22, 2019·Scientific Reports·Eva PolandMelanie Wilke
Jun 8, 2011·The European Journal of Neuroscience·Eric I Knudsen
Aug 4, 2018·Frontiers in Systems Neuroscience·Chantal Milleret, Emmanuel Bui Quoc
Feb 4, 2021·Journal of Neurophysiology·Ziad M HafedTong Zhang
Aug 1, 2020·Current Biology : CB·Robert L WhitwellMelvyn A Goodale

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