Exploring the quantitative relationship between metabolism and enzymatic phenotype by physiological modeling of glucose metabolism and lactate oxidation in solid tumors

Physics in Medicine and Biology
Qian WangKuangyu Shi

Abstract

Molecular imaging using PET or hyperpolarized MRI can characterize tumor phenotypes by assessing the related metabolism of certain substrates. However, the interpretation of the substrate turnover in terms of a pathophysiological understanding is not straightforward and only semiquantitative. The metabolism of imaging probes is influenced by a number of factors, such as the microvascular structure or the expression of key enzymes. This study aims to use computational simulation to investigate the relationship between the metabolism behind molecular imaging and the underlying tumor phenotype. The study focused on the pathways of glucose metabolism and lactate oxidation in order to establish the quantitative relationship between the expression of several transporters (GLUT, MCT1 and MCT4), expression of the enzyme hexokinase (HK), microvasculature and the metabolism of glucose or lactate and the extracellular pH distribution. A computational model for a 2D tumor tissue phantom was constructed and the spatio-temporal evolution of related species (e.g. oxygen, glucose, lactate, protons, bicarbonate ions) was estimated by solving reaction-diffusion equations. The proposed model was tested by the verification of the simulation result...Continue Reading

References

Nov 25, 1977·Pflügers Archiv : European journal of physiology·J GroteP Vaupel
Aug 15, 1989·International Journal of Cancer. Journal International Du Cancer·F KallinowskiP Vaupel
Jan 28, 1972·Biochimica Et Biophysica Acta·L C Garg, T H Maren
Oct 1, 1983·Journal of Pharmaceutical Sciences·L E Gerlowski, R K Jain
Jun 20, 1998·The Journal of Biological Chemistry·M C WilsonA P Halestrap
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S R RiddleC W White
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·D Rivenzon-SegalH Degani
Oct 18, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M Nordsmark, J Overgaard
May 18, 2001·British Journal of Cancer·M A KonerdingA Gaumann
Feb 1, 2002·European Journal of Applied Physiology·A Bonen
Mar 1, 2003·Physics in Medicine and Biology·Alexandru DaşuJack F Fowler
Apr 6, 2004·Methods in Enzymology·Peter VaupelMichael Höckel
Jul 16, 2004·Seminars in Radiation Oncology·Peter Vaupel
Dec 14, 2004·The Oncologist·Peter Vaupel
Oct 28, 2006·Physics in Medicine and Biology·Catherine J Kelly, Michael Brady
Jan 18, 2007·Physics in Medicine and Biology·Belma DogdasRichard M Leahy
Jun 1, 2007·Antioxidants & Redox Signaling·Peter VaupelArnulf Mayer
Jul 22, 2008·Journal of Theoretical Biology·Catherine KellyMichael Brady
Mar 19, 2009·Physics in Medicine and Biology·Steven F PetitBradly G Wouters
Aug 15, 2009·Journal of Cellular Physiology·Sara Rodríguez-EnríquezRafael Moreno-Sánchez
Nov 19, 2009·Cancer Research·Hamid R MolavianSivabal Sivaloganathan
Dec 19, 2009·Journal of Intensive Care Medicine·Allan J WalkeyGeorge J Philippides
Feb 25, 2010·Nature Reviews. Cancer·Helen M Byrne
Jul 28, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xiaomeng ZhangRobert J Gillies
Mar 10, 2011·Physics in Medicine and Biology·David MönnichDaniela Thorwarth
Mar 26, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Constantin-Alin MafteiPeter Vaupel
Apr 2, 2011·The Journal of Biological Chemistry·Ying LiSusan C Frost
May 17, 2011·Molecular Cancer Research : MCR·Qun LinZhong Yun
Mar 9, 2012·Physics in Medicine and Biology·David MönnichDaniela Thorwarth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

© 2021 Meta ULC. All rights reserved