Exploring the Relationship Between Body Mass Index and Positive Symptom Severity in Persons at Clinical High Risk for Psychosis

The Journal of Nervous and Mental Disease
Fernando CaravaggioRagy Girgis

Abstract

Metabolic health and positive symptom severity has been investigated in schizophrenia, but not in clinical high risk (CHR) patients. We hypothesized that greater body mass index (BMI) in CHR patients would be related to less positive symptoms. We examined this relationship in CHR patients being treated with 1) no psychotropic medications (n = 58), 2) an antipsychotic (n = 14), or 3) an antidepressant without an antipsychotic (n = 10). We found no relationship between BMI and positive symptoms in unmedicated CHR patients, the majority of whom had a narrow BMI range between 20 and 30. However, in the smaller sample of CHR patients taking an antidepressant or antipsychotic, BMI was negatively correlated with positive symptoms. Although potentially underpowered, these preliminary findings provide initial steps in elucidating the relationships between metabolic health, neurochemistry, and symptom severity in CHR patients.

References

Apr 26, 2001·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·R S McIntyreS H Kennedy
Jan 30, 2004·Diabetes Care·UNKNOWN American Diabetes AssociationUNKNOWN North American Association for the Study of Obesity
Jul 14, 2007·International Journal of Clinical Practice·A TschonerC F Ebenbichler
Feb 27, 2015·The International Journal of Neuropsychopharmacology·Fernando CaravaggioAriel Graff-Guerrero
Jun 24, 2015·Endocrine, Metabolic & Immune Disorders Drug Targets·Hubertus HimmerichKenneth C Kirkby

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Citations

Sep 20, 2020·Translational Psychiatry·Brandon J CoombesJoanna M Biernacka
Aug 15, 2018·Schizophrenia Bulletin·Christian NúñezUNKNOWN PEPs group
Jun 4, 2019·Neuropharmacology·Sri Mahavir AgarwalMargaret Hahn
Jan 29, 2021·Neuropsychopharmacology Reports·Taro KishiNakao Iwata

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