Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer

International Journal of Molecular Sciences
Michela CoanMilena Sabrina Nicoloso

Abstract

High-grade serous epithelial ovarian cancer (HGSOC) is the fifth leading cause of cancer death in women and the first among gynecological malignancies. Despite an initial response to standard chemotherapy, most HGSOC patients relapse. To improve treatment options, we must continue investigating tumor biology. Tumor characteristics (e.g., risk factors and epidemiology) are valuable clues to accomplish this task. The two most frequent risk factors for HGSOC are the lifetime number of ovulations, which is associated with increased oxidative stress in the pelvic area caused by ovulation fluid, and a positive family history due to genetic factors. In the attempt to identify novel genetic factors (i.e., genes) associated with HGSOC, we observed that several genes in linkage with HGSOC are expressed in the ciliated cells of the fallopian tube. This finding made us hypothesize that ciliated cells, despite not being the cell of origin for HGSOC, may take part in HGSOC tumor initiation. Specifically, malfunction of the ciliary beat impairs the laminar fluid flow above the fallopian tube epithelia, thus likely reducing the clearance of oxidative stress caused by follicular fluid. Herein, we review the up-to-date findings dealing with HGSO...Continue Reading

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Citations

May 1, 2020·The Journal of Reproduction and Development·Sevastiani AntonouliGuido Macchiarelli
Apr 1, 2020·International Journal of Environmental Research and Public Health·Chen-Yu HuangPeng-Hui Wang
Dec 19, 2020·The Journal of Obstetrics and Gynaecology Research·Cagdas SahinYasemin Akcay
Oct 30, 2019·Molecular Therapy Oncolytics·Da-Fang ZhengYi-Sheng Tao
Mar 28, 2021·Fertility and Sterility·Jessica A LentscherGregory E Chow
Aug 20, 2019·Current Medicinal Chemistry·Maria Grazia PerroneAntonio Scilimati

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Datasets Mentioned

BETA
GSE10971
GSE69428

Methods Mentioned

BETA
acetylation

Software Mentioned

GeneCards

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