Exploring the role of the histidine biosynthetic hisF gene in cellular metabolism and in the evolution of (ancestral) genes: from LUCA to the extant (micro)organisms.

Microbiological Research
Sofia ChioccioliRenato Fani

Abstract

Histidine biosynthesis is an ancestral pathway that was assembled before the appearance of the Last Universal Common Ancestor; afterwards, it remained unaltered in all the extant histidine-synthesizing (micro)organisms. It is a metabolic cross-road interconnecting histidine biosynthesis to nitrogen metabolism and the de novo synthesis of purines. This interconnection is due to the reaction catalyzed by the products of hisH and hisF genes. The latter gene is an excellent model to study which trajectories have been followed by primordial cells to build the first metabolic routes, since its evolution is the result of different molecular rearrangement events, i.e. gene duplication, gene fusion, gene elongation, and domain shuffling. Additionally, this review summarizes data concerning the involvement of hisF and its product in other different cellular processes, revealing that HisF very likely plays a role also in cell division control and involvement in virulence and nodule development in different bacteria. From the metabolic viewpoint, these results suggest that HisF plays a central role in cellular metabolism, highlighting the interconnections of different metabolic pathways.

References

Jan 1, 1976·Annual Review of Microbiology·R A Jensen
Oct 5, 1988·Journal of Molecular Biology·M S CarlomagnoC B Bruni
Mar 1, 1974·Journal of Theoretical Biology·M Ycas
Feb 1, 1995·Protein Science : a Publication of the Protein Society·P BorkF Martin
Sep 1, 1993·Molecular & General Genetics : MGG·N Frandsen, R D'Ari
Sep 1, 1993·Molecular & General Genetics : MGG·M FoxR D'Ari
Dec 1, 1995·Journal of Molecular Evolution·R FaniA Lazcano
Mar 1, 1996·Microbiological Reviews·P AlifanoC B Bruni
Sep 22, 1998·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·R FaniA Lazcano
Mar 4, 2000·Nature Structural Biology·J A Gerlt
Jan 3, 2001·Nature Structural Biology·J A Gerlt, P C Babbitt
Jan 3, 2001·Nature Structural Biology·B HöckerR Sterner
Sep 1, 1990·Journal of Molecular Evolution·C ShenJ Oro
Dec 1, 1994·Journal of Molecular Evolution·A Lazcano, S L Miller
May 31, 2002·Molecular Plant-microbe Interactions : MPMI·Simona FerraioliEduardo J Patriarca
Jan 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shailendra GiriInderjit Singh
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Jun 1, 1945·Proceedings of the National Academy of Sciences of the United States of America·N H Horowitz
Sep 16, 2008·The International Journal of Biochemistry & Cell Biology·Gustavo Caetano-AnollésJay E Mittenthal
May 15, 2009·Clinical and Experimental Immunology·A PeairsC M Reilly
Jan 8, 2009·Physics of Life Reviews·Renato Fani, Marco Fondi
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ivan RivaltaVictor S Batista
Apr 27, 2013·Microbial Biotechnology·Robert K Kulis-HornJörn Kalinowski
Dec 25, 2013·Journal of the American Chemical Society·Bernd ReisingerReinhard Sterner
May 8, 2015·Nature Protocols·Lawrence A KelleyMichael J E Sternberg
Aug 1, 2009·EcoSal Plus·Malcolm E Winkler, Smirla Ramos-Montañez
Jan 7, 2016·Journal of Molecular Evolution·Aaron David GoldmanLaura F Landweber
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·George P LisiJ Patrick Loria
Jul 5, 2019·International Journal of Molecular Sciences·Lisa Maria MartinEllen Niederberger

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