Exploring the secrets of long noncoding RNAs

International Journal of Molecular Sciences
Mingyang QuanDeqiang Zhang

Abstract

High-throughput sequencing has revealed that the majority of RNAs have no capacity to encode protein. Among these non-coding transcripts, recent work has focused on the roles of long noncoding RNAs (lncRNAs) of >200 nucleotides. Although many of their attributes, such as patterns of expression, remain largely unknown, lncRNAs have key functions in transcriptional, post-transcriptional, and epigenetic gene regulation; Also, new work indicates their functions in scaffolding ribonuclear protein complexes. In plants, genome-wide identification of lncRNAs has been conducted in several species, including Zea mays, and recent research showed that lncRNAs regulate flowering time in the photoperiod pathway, and function in nodulation. In this review, we discuss the basic mechanisms by which lncRNAs regulate key cellular processes, using the large body of knowledge on animal and yeast lncRNAs to illustrate the significance of emerging work on lncRNAs in plants.

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Mar 8, 2016·BioMed Research International·Youyou YanBin Liu
Nov 6, 2018·Journal of Cellular and Molecular Medicine·Xin RuiJiangyong Leng
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Methods Mentioned

BETA
RNA-seq
histone acetylation

Software Mentioned

COLDAIR
COOLAIR
Python
SVM

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