PMID: 7021430Jul 1, 1981Paper

Exponential model for a two-ligand, regulatory enzyme. Part 3: Performance tests of INDEXP computer programs for determination of model constants from initial velocity data. 2. Experimental data

International Journal of Bio-medical Computing
S AinsworthR B Gregory

Abstract

The exponential model for a regulatory enzyme describes the relationship between the initial velocity of the catalysed reaction and the concentration of two ligands. A program, entitled 'INDEXP' has been devised to analyse rate data in terms of the model (Kinderlerer et al., 1981) and, in this report, its performance is examined when presented with experimental initial velocity data taken from the literature. It is shown that the two-ligand exponential model can satisfactorily rationalise experimental data with five linked constants (Ainsworth and Gregory, 1978); as a result the influence of ligand concentrations on the catalysed reactions can be described in rather simple terms.

References

Oct 15, 1975·European Journal of Biochemistry·H G Nimmo, K F Tipton
Nov 1, 1975·The Biochemical Journal·P C Engel, S S Chen
Oct 15, 1975·European Journal of Biochemistry·H G Nimmo, K F Tipton
Jan 1, 1979·International Journal of Bio-medical Computing·J Kinderlerer, S Ainsworth
Oct 7, 1977·Journal of Theoretical Biology·S Ainsworth
Sep 1, 1978·Archives of Biochemistry and Biophysics·M L CárdenasH Niemeyer
Nov 7, 1978·Journal of Theoretical Biology·S Ainsworth, R B Gregory
Jul 1, 1970·Canadian Journal of Biochemistry·H D EngersN B Madsen
Jun 1, 1968·Biochemistry·B E MetzgerE Helmreich
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Nov 1, 1971·Archives of Biochemistry and Biophysics·C J Thompson, I M Klotz
Jan 1, 1964·Advances in Protein Chemistry·J WYMAN

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