Exponential trajectories, cell size fluctuations, and the adder property in bacteria follow from simple chemical dynamics and division control.

Physical Review. E
Parth Pratim PandeySanjay Jain

Abstract

Experiments on steady-state bacterial cultures have uncovered several quantitative regularities at the system level. These include, first, the exponential growth of cell size with time and the balanced growth of intracellular chemicals between cell birth and division, which are puzzling given the nonlinear and decentralized chemical dynamics in the cell. We model a cell as a set of chemical populations undergoing nonlinear mass action kinetics in a container whose volume is a linear function of the chemical populations. This turns out to be a special class of dynamical systems that generically has attractors in which all populations grow exponentially with time at the same rate. This explains exponential balanced growth of bacterial cells without invoking any regulatory mechanisms and suggests that this could be a robust property of protocells as well. Second, we consider the hypothesis that cells commit themselves to division when a certain internal chemical population reaches a threshold of N molecules. We show that this hypothesis leads to a simple explanation of some of the variability observed across cells in a bacterial culture. In particular, it reproduces the adder property of cell size fluctuations observed recently in...Continue Reading

References

Jan 31, 1973·Nature: New Biology·L Sompayrac, O Maaloe
Feb 14, 1968·Journal of Molecular Biology·S Cooper, C E Helmstetter
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Thattai, A van Oudenaarden
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter S SwainEric D Siggia
Mar 14, 2003·Physical Review Letters·Chikara Furusawa, Kunihiko Kaneko
May 7, 2003·Current Opinion in Microbiology·William D Donachie, Garry W Blakely
Aug 19, 2003·International Review of Cytology·J M Mitchison
Nov 1, 1962·Journal of General Microbiology·M SCHAECHTERA L KOCH
Oct 8, 2004·Biotechnology and Bioengineering·Samuel T BrowningMichael L Shuler
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·William Margolin
Feb 8, 2006·The Journal of Chemical Physics·Yang CaoLinda R Petzold
Mar 16, 2007·Artificial Life·Roberto SerraIrene Poli
May 19, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Fabio Mavelli, Kepa Ruiz-Mirazo
Aug 2, 2008·Journal of Theoretical Biology·T CarlettiA Filisetti
Jun 30, 2009·Nature Chemical Biology·Bryson D BennettJoshua D Rabinowitz
Oct 27, 2009·Nucleic Acids Research·Ron MiloMichael Springer
Nov 6, 2009·Molecular Systems Biology·Douwe MolenaarBas Teusink
Apr 13, 2010·Nature Methods·Michel GodinScott R Manalis
Jun 12, 2010·Current Biology : CB·Ping WangSuckjoon Jun
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Harold P EricksonMasaki Osawa
Dec 28, 2010·Nature Genetics·Dann Huh, Johan Paulsson
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mustafa MirGabriel Popescu
Dec 23, 2011·BMC Systems Biology·Matthew A A GrantMarco Cosentino Lagomarsino
Jul 24, 2012·Cell·Jonathan R KarrMarkus W Covert
Sep 26, 2012·Physical Review Letters·Hanna SalmanErez Braun
Dec 13, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Fabio Mavelli, Kepa Ruiz-Mirazo
Mar 9, 2013·Cold Spring Harbor Perspectives in Biology·Kirsten Skarstad, Tsutomu Katayama
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matteo OsellaMarco Cosentino Lagomarsino
Apr 9, 2014·PloS One·Jean-Bernard Nobs, Sebastian J Maerkl
Jul 26, 2014·Physical Review Letters·Srividya Iyer-BiswasAaron R Dinner
Aug 26, 2014·Molecular Systems Biology·Matthew ScottTerence Hwa
Sep 5, 2014·Nature·Daniel J KivietSander J Tans
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Srividya Iyer-BiswasNorbert F Scherer
Dec 7, 2014·Cell·Manuel CamposChristine Jacobs-Wagner
Dec 30, 2014·Current Biology : CB·Sattar Taheri-AraghiSuckjoon Jun
Dec 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Arijit Maitra, Ken A Dill
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Rami Pugatch
Feb 20, 2015·Proceedings of the National Academy of Sciences of the United States of America·Andrea Y WeißePeter S Swain
Jul 29, 2015·Frontiers in Microbiology·Po-Yi Ho, Ariel Amir

❮ Previous
Next ❯

Citations

Sep 30, 2020·FEMS Microbiology Reviews·Alix MeunierManuel Campos
May 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mia PanlilioMarco Cosentino Lagomarsino
Aug 15, 2021·Proceedings of the National Academy of Sciences of the United States of America·Anjan RoyRami Pugatch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.