Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission

Nature
Douglas G PatonFlaminia Catteruccia

Abstract

Bites of Anopheles mosquitoes transmit Plasmodium falciparum parasites that cause malaria, which kills hundreds of thousands of people every year. Since the turn of this century, efforts to prevent the transmission of these parasites via the mass distribution of insecticide-treated bed nets have been extremely successful, and have led to an unprecedented reduction in deaths from malaria1. However, resistance to insecticides has become widespread in Anopheles populations2-4, which has led to the threat of a global resurgence of malaria and makes the generation of effective tools for controlling this disease an urgent public health priority. Here we show that the development of P. falciparum can be rapidly and completely blocked when female Anopheles gambiae mosquitoes take up low concentrations of specific antimalarials from treated surfaces-conditions that simulate contact with a bed net. Mosquito exposure to atovaquone before, or shortly after, P. falciparum infection causes full parasite arrest in the midgut, and prevents transmission of infection. Similar transmission-blocking effects are achieved using other cytochrome b inhibitors, which demonstrates that parasite mitochondrial function is a suitable target for killing par...Continue Reading

References

Aug 20, 1976·Science·W Trager, J B Jensen
Nov 26, 1981·Nature·T Ifediba, J P Vanderberg
May 1, 1993·The American Journal of Tropical Medicine and Hygiene·C BoudinP Ambroise-Thomas
Aug 26, 2006·The American Journal of Tropical Medicine and Hygiene·Gerry F KilleenThomas Smith
Jun 7, 2008·Malaria Journal·Wim Van BortelMarc Coosemans
Nov 4, 2010·Nature Communications·David L SmithSimon I Hay
Jul 21, 2011·The Journal of Biological Chemistry·Katja E Boysen, Kai Matuschewski
Aug 27, 2011·ACS Chemical Biology·Tae-Gyu NamElizabeth A Winzeler
Nov 13, 2012·PLoS Neglected Tropical Diseases·Matthias WitschelReto Brun
Oct 4, 2014·Emerging Infectious Diseases·Kobié H ToéHilary Ranson
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Angelika SturmGeoffrey I McFadden
Jun 2, 2015·International Journal of Environmental Research and Public Health·Céline Christiansen-JuchtPaul E Parham
Jun 18, 2015·Parasites & Vectors·Cherry L DykesOm P Singh
Apr 16, 2016·Science·Christopher D GoodmanGeoffrey I McFadden
Dec 16, 2016·PLoS Pathogens·Lauren M ChildsFlaminia Catteruccia
Apr 11, 2017·International Journal of Environmental Research and Public Health·Jodi M FiorenzanoRui-De Xue
Sep 21, 2017·Parasites & Vectors·Benyl M OndetoCharles M Mbogo

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Citations

Jul 16, 2020·Journal of Medical Entomology·Ryan C Smith
Sep 23, 2020·Pharmaceuticals·Phanankosi MoyoLyn-Marié Birkholtz
Sep 29, 2020·Evolution, Medicine, and Public Health·Alejandro L Antonia, Dennis C Ko
Mar 7, 2019·Nature Reviews. Microbiology·Andrea du Toit
Jul 3, 2019·The American Journal of Tropical Medicine and Hygiene·Jeremy BurrowsSarah Rees
Jan 16, 2020·Nature·Flaminia Catteruccia
Sep 19, 2019·International Health·Janet Hemingway
Sep 12, 2020·Parasites & Vectors·Eunice Oluwatobiloba AdedejiEzekiel Adebiyi
Dec 4, 2019·Nature Microbiology·Gregory P D MurrayPhilip J McCall
Oct 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jingxiang YangBart Kahr
Oct 24, 2020·Tropical Medicine and Infectious Disease·Elerson Matos RochaJayme A Souza-Neto
Aug 6, 2019·Molecular and Biochemical Parasitology·Jenni A Hayward, Giel G van Dooren
Jan 21, 2021·Viruses·Shengzhang Dong, George Dimopoulos
Dec 29, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert T JonesJames G Logan
May 5, 2021·Trends in Parasitology·Johannes T DessensSadia Saeed
May 14, 2021·AMB Express·Hamed Memariani, Mojtaba Memariani
Sep 7, 2019·Journal of Medicinal Chemistry·Ainoa Rueda-ZubiaurreMatthew J Fuchter

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Methods Mentioned

BETA
PCR
dissecting
dissection

Software Mentioned

GraphPad Prism
GraphPad
JMP Pro
IR Mapper

Related Concepts

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Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.