Exposure assessment approaches for engineered nanomaterials

Risk Analysis : an Official Publication of the Society for Risk Analysis
Linda C Abbott, Andrew Maynard

Abstract

Products based on nanotechnology are rapidly emerging in the marketplace, sometimes with little notice to consumers of their nanotechnology pedigree. This wide variety of nanotechnology products will result (in some cases) in unintentional human exposure to purposely engineered nanoscale materials via the dermal, inhalation, ingestion, and ocular pathways. Occupational, consumer, and environmental exposure to the nanomaterials should be characterized during the entire product lifecycle-manufacture, use, and disposal. Monitoring the fate and transport of engineered nanomaterials is complicated by the lack of detection techniques and the lack of a defined set of standardized metrics to be consistently measured. New exposure metrics may be required for engineered nanomaterials, but progress is possible by building on existing tools. An exposure metric matrix could organize existing data by relating likely exposure pathways (dermal, inhalation, ocular, ingestion) with existing measurements of important characteristics of nanoscale materials (particle number, mass, size distribution, charge). Nanomaterial characteristics not commonly measured, but shown to initiate a biological response during toxicity testing, signal a need for fur...Continue Reading

References

Sep 1, 1991·The American Review of Respiratory Disease·C A PopeM E Raizenne
Oct 1, 1991·Environmental Research·J SchwartzE Malin
Mar 1, 1989·The American Review of Respiratory Disease·D W DockeryB G Ferris
Jan 21, 1995·Lancet·A SeatonD Godden
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
Apr 1, 1993·The American Review of Respiratory Disease·J SchwartzJ Q Koenig
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·I RomieuR A Etzel
Oct 1, 1996·Journal of the Air & Waste Management Association·J SchwartzL M Neas
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·A PetersJ Heyder
May 24, 2001·Applied Occupational and Environmental Hygiene·M A McCawleyM T Berakis
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Feb 15, 2003·Critical Reviews in Toxicology·James M Antonini
May 24, 2003·The European Respiratory Journal. Supplement·W MacNee, K Donaldson
Jul 5, 2003·Environmental Health Perspectives·Sally S TinkleEric J Adkins
Dec 9, 2003·Nature Biotechnology·Sungjee KimJohn V Frangioni
May 7, 2004·Applied and Environmental Microbiology·Cristian PicioreanuMark C M Van Loosdrecht
Jun 19, 2004·Inhalation Toxicology·G OberdörsterC Cox
Sep 3, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·R Alvarez-RománH Fessi
Oct 28, 2004·Environmental Science & Technology·Hélène F LecoanetMark R Wiesner
May 18, 2005·International Journal of Pharmaceutics·E Garcia-GarciaP Couvreur
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Oct 8, 2005·Particle and Fibre Toxicology·Günter OberdörsterUNKNOWN ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group
Jan 31, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jessica P Ryman-RasmussenNancy A Monteiro-Riviere
Feb 16, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Treye ThomasRobert Bronaugh
Feb 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·David B WarheitKenneth L Reed
Aug 3, 2006·Environmental Health Perspectives·Alison ElderGünter Oberdörster
Aug 16, 2006·Particle and Fibre Toxicology·Paul J A BormEva Oberdorster
Nov 17, 2006·Nature·Andrew D MaynardDavid B Warheit
Jan 30, 2007·Environmental Science & Technology·Katherine A Dunphy GuzmanJillian F Banfield
Feb 3, 2007·Environmental Science & Technology·Hoon HyungJae-Hong Kim
Apr 25, 2007·Journal of Nanoscience and Nanotechnology·J Michael Davis
Sep 19, 2007·Environmental Science & Technology·Richard Owen, Richard Handy
Mar 4, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Qasim ChaudhryRichard Watkins
Jun 5, 2008·Skin Pharmacology and Physiology·G J NohynekM S Roberts
Jun 5, 2008·Skin Pharmacology and Physiology·L W Zhang, N A Monteiro-Riviere
Jul 2, 2008·Environmental Science & Technology·Troy M Benn, Paul Westerhoff
Jul 26, 2008·Nature Nanotechnology·R David HolbrookKen D Cole

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Occupational and Environmental Hygiene·Pieter van Broekhuizen, Bärbel Dorbeck-Jung
Apr 10, 2012·Annual Review of Analytical Chemistry·H Zänker, A Schierz
Jun 1, 2013·ISRN Toxicology·Sachindri Rana, P T Kalaichelvan
Jul 20, 2014·Journal of Hazardous Materials·Virginia GomezJesus Santamaria
Nov 29, 2013·The Annals of Occupational Hygiene·Michele Noble Shepard, Sara Brenner
Mar 5, 2013·The Science of the Total Environment·Christine Ogilvie HendrenMark R Wiesner
Nov 8, 2012·Journal of Biochemical and Molecular Toxicology·Ali A AlshatwiAbdulrahman A Alwarthan
May 2, 2013·Integrated Environmental Assessment and Management·Johannes A J MeestersDik van de Meent
Mar 27, 2012·Environmental Toxicology and Chemistry·Joris T K QuikDik van de Meent
Mar 16, 2012·Journal of Food Science·Bernadene A MagnusonJeffrey W Card
Mar 27, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Enrico BergamaschiSyed A M Tofail
Apr 9, 2016·Advanced Drug Delivery Reviews·Hélène MalhaireFrédéric Lagarce
Aug 25, 2015·Frontiers in Chemistry·Catia Contado
Jan 15, 2014·The Science of the Total Environment·Eric S MoneyMark R Wiesner
Jan 31, 2015·Journal of Occupational and Environmental Hygiene·Amanda JuricEric N Liberda
Jan 17, 2015·Environmental Science and Pollution Research International·Corinna BurkartDirk Jungmann
Sep 12, 2012·Environmental Toxicology and Pharmacology·Khaled RadadWolf-Dieter Rausch
May 14, 2016·Journal of Occupational and Environmental Hygiene·Sara A BrennerCharles L Geraci
Oct 1, 2016·Pharmaceuticals·Michail Karavolos, Alina Holban
May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jingliang DongChunying Chen
Apr 29, 2014·Environmental Science & Technology·Johannes A J MeestersDik van de Meent
Jan 1, 2013·Environmental Science. Processes & Impacts·Katrien LuytsPeter H M Hoet
Feb 18, 2016·Risk Analysis : an Official Publication of the Society for Risk Analysis·Serkan ErbisSagar Kamarthi
Jan 8, 2013·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Gary E Marchant, Rachel A Lindor
Jul 20, 2019·Carbohydrate Polymers·Alexandro B de SouzaMaria Helena A Santana
Jul 2, 2019·ACS Applied Materials & Interfaces·Mohamed H LahianiSangeeta Khare

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.