Exposure Assessment in Japan Environment and Children's Study

Nihon eiseigaku zasshi. Japanese journal of hygiene
Shoji F NakayamaAyano Takeuchi

Abstract

In this review, we present an initial plan for exposure assessment in the Japan Environment and Children's Study (JECS) by focusing on a biomonitoring technique and discuss the challenges encountered when using the biomonitoring technique for exposure measurements. JECS registered 103,099 pregnant mothers and has been following children born to them. Various biological samples were collected from mothers during pregnancy (blood and urine), at birth (blood and hair) and at check-up one month after birth (breast milk). Samples were also collected from children at birth (cord blood) and at check-up one month after birth (hair and blood spot). Those samples will be used to assess maternal and foetal exposures to chemical substances. Measurement reliability, i.e., intraclass correlation coefficient (ICC), and attenuation bias related to low ICCs should be taken into consideration when using the biomonitoring results. Along with the biomonitoring technique, simulation models, pharmacokinetic (PK) models and exposomics techniques are under development in JECS. New analytical techniques include deciduous teeth measurements and -omics analyses. In particular, PK models and sensor technologies are one of the most important methodologies ...Continue Reading

References

Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christopher Paul Wild
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·John M Lachin
Jan 26, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Daniel Kwok-Keung NgRobert Shing-Yan Lee
Jul 2, 2009·Environmental Health and Preventive Medicine·Yayoi SuzukiHiroaki Shiraishi
Jan 6, 2011·Environmental Health Perspectives·Joe M BraunBruce P Lanphear
Feb 1, 2012·Environmental Health Perspectives·Timothy CiesielskiRobert O Wright
Feb 23, 2013·Current Opinion in Pediatrics·Manish Arora, Christine Austin
Aug 22, 2013·Environmental Health : a Global Access Science Source·Chris GenningsBarbara A Cohn
Jan 15, 2014·BMC Public Health·Toshihiro KawamotoUNKNOWN Working Group of the Epidemiological Research for Children’s Environmental Health
Nov 6, 2014·Critical Reviews in Toxicology·Cathrine Carlsen BachTine Brink Henriksen
May 26, 2015·Cancer Informatics·Jenna CzarnotaDavid C Wheeler
Feb 10, 2016·Current Opinion in Pediatrics·Syam S AndraManish Arora
Feb 13, 2016·Epigenomics·Srikant AmbatipudiZdenko Herceg
Jun 9, 2016·Critical Reviews in Toxicology·Cathrine Carlsen BachGunnar Toft
Dec 7, 2016·International Journal of Hygiene and Environmental Health·Clémentine DereumeauxSébastien Denys
Apr 4, 2017·Environmental Research·Ghalib A BelloChris Gennings
Apr 27, 2017·Annals of Pediatric Endocrinology & Metabolism·Jung Eun Lee, Kyungho Choi
Jun 28, 2017·International Journal of Environmental Research and Public Health·Kristen M RappazzoErin P Hines
Nov 3, 2017·Journal of Epidemiology·Takehiro MichikawaUNKNOWN Japan Environment and Children’s Study Group

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