Exposure, epidemiology and human cancer incidence of naphthalene

Regulatory Toxicology and Pharmacology : RTP
Fumie Y GriegoDouglas L Weed

Abstract

This report provides a summary of deliberations conducted under the charge for members of Module B participating in the Naphthalene State-of-the-Science Symposium (NS(3)), Monterey, CA, October 9-12, 2006. The panel's charge was to derive consensus estimates of human exposure to naphthalene under various conditions, cancer incidence plausibly associated with these exposures, and identify quintessential research that could significantly reduce or eliminate material uncertainties to inform human cancer risk assessment. Relying in large part on a commissioned paper [Price, P.S., Jayjock, M.A., 2008. Available data on naphthalene exposures: strengths and limitations, in this issue], exposure levels were estimated for background (0.0001-0.003 microg/m(3)), ambient air (0.001-1.0 microg/m(3)), vehicles (0.003-3.0 microg/m(3)), residences (0.1-10 microg/m(3)), mothball use (on-label: 1-100 microg/m(3); off-label: 10-100 microg/m(3)), and occupational (low: 3-100 microg/m(3); high: 30-1,000 microg/m(3)). There have been few published reports of human cancer associated with naphthalene exposure. Several research projects are suggested that could reduce uncertainty in our understanding of human exposure. Using best scientific judgment, i...Continue Reading

References

Dec 15, 2007·Regulatory Toxicology and Pharmacology : RTP·Paul S Price, Michael A Jayjock
Feb 5, 2008·Regulatory Toxicology and Pharmacology : RTP·Richard B BelzerRichard C Pleus

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Feb 5, 2008·Regulatory Toxicology and Pharmacology : RTP·Richard B BelzerRichard C Pleus
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Dec 15, 2007·Regulatory Toxicology and Pharmacology : RTP·Paul S Price, Michael A Jayjock
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