PMID: 3212840Jan 1, 1988Paper

Exposure levels for ultrasonic cavitation in the mouse neonate

Ultrasound in Medicine & Biology
C Lee, L A Frizzell

Abstract

The levels for hind limb paralysis from 1 MHz, continuous wave, unfocused ultrasound in the neonatal mouse were determined at 1 and 16 bars hydrostatic pressure and at 10 and 37 degrees C. Above a specific intensity level at each temperature, the exposure duration for paralysis of 50% of specimens exposed (t50) was found to be greater at 16 bars than at 1 bar suggesting a threshold for cavitational involvement. Using these results, the intensity thresholds for cavitation were found to be in the ranges of 120-150 W/cm2 and 53-74 W/cm2 at 10 degrees C and 37 degrees C, respectively. This temperature dependence is consistent with a cavitation mechanism. In addition, the t50 at 289 W/cm2 and 10 degrees C was measured as a function of hydrostatic pressure and showed that cavitation was suppressed at hydrostatic pressures above approximately 10 bars. This result and the intensity threshold for cavitation at 1 bar and 10 degrees C yielded similar values for the threshold negative total pressure for cavitation in the neonatal mouse.

References

Jul 1, 1971·IEEE Transactions on Bio-medical Engineering·F Dunn, F J Fry
Dec 1, 1970·The Journal of the Acoustical Society of America·F J FryF Dunn
Sep 1, 1983·The Journal of the Acoustical Society of America·L A FrizzellF Dunn
Jan 1, 1981·Ultrasound in Medicine & Biology·V CiaravinoM W Miller
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Jan 1, 1988·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·L A Frizzell
Jan 1, 1986·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·R E Appel
Jan 1, 1986·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·G R Ter HarrK Morton

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Citations

Dec 5, 1998·Ultrasound in Medicine & Biology
Nov 26, 1999·Ultrasound in Medicine & Biology·D L MillerR A Gies
Nov 10, 2009·Prenatal Diagnosis·Laura E HoustonGeorge A Macones
Jan 1, 1990·Ultrasound in Medicine & Biology·B E BillardR B Roemer
Jan 1, 1993·Ultrasound in Medicine & Biology·D J WatmoughA P Sarvazyan
Jan 1, 1991·Ultrasound in Medicine & Biology·R M QuainM W Miller
Aug 26, 2011·Anesthesiology·Hariharan Shankar, Paul S Pagel
Sep 29, 2000·The Journal of the Acoustical Society of America·W D O'BrienJ F Zachary
Dec 6, 2017·Drug Delivery and Translational Research·Ankit JainSanjay K Jain
Mar 25, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Charles C ChurchMichael R Bailey
Oct 19, 2006·Progress in Biophysics and Molecular Biology·Timothy G Leighton

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