Exposure of Ancistrus multispinis (Regan, 1912, Pisces, Teleostei) to deltamethrin: effects on cellular immunity

Fish & Shellfish Immunology
Cláudia Turra PimpãoHelena Cristina Silva de Assis

Abstract

The objective of this study performed in Ancistrus multispinis was to evaluate whether sublethal doses of deltamethrin (DM) could affect lipopolysaccharide (LPS)-induced leukocyte migration to the peritoneal cavity and the production of nitric oxide (NO) by kidney macrophages exposed to LPS and/or DM. For cell migration studies, 10 fish were exposed to DM 0.1 or 0.3 mg kg(-1) or vehicle for 96 h. After this period, each group received LPS (0.1 microg kg(-1)) or saline and the cells were collected after 4h. For the production of NO, kidney macrophages were isolated from eight fish and the cells were incubated for 24 or 48 h with LPS (10 microg mL(-1)) and DM (0.3 and 1 microg mL(-1)). The results were analyzed using ANOVA followed by Bonferroni multiple comparisons test. A small leukocyte population (530+/-30.8 cells microL(-1)) was naturally observed in the peritoneal cavity, however after inoculation of LPS, the number of leukocytes was increased by 157%. For the fish treated with DM 0.1 and 0.3 mg kg(-1), total leukocytes had increased by 100 and 162%, respectively. The combination of LPS with the higher dose of DM showed a potentiating or additive effect. The production of NO was increased in all the treated groups in relati...Continue Reading

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Citations

Jul 20, 2014·Fish & Shellfish Immunology·João Luiz Coelho RibasHelena C Silva de Assis
Apr 21, 2017·Critical Reviews in Toxicology·Kristina RehbergerLisa Baumann
Sep 12, 2020·Environmental Science and Pollution Research International·Faten AlnoaimiTurgay Şişman
Apr 28, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Changwon YangGwonhwa Song

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