Exposure of phosphatidylserine on the cell surface

Cell Death and Differentiation
Shigekazu NagataT Fujii

Abstract

Phosphatidylserine (PtdSer) is a phospholipid that is abundant in eukaryotic plasma membranes. An ATP-dependent enzyme called flippase normally keeps PtdSer inside the cell, but PtdSer is exposed by the action of scramblase on the cell's surface in biological processes such as apoptosis and platelet activation. Once exposed to the cell surface, PtdSer acts as an 'eat me' signal on dead cells, and creates a scaffold for blood-clotting factors on activated platelets. The molecular identities of the flippase and scramblase that work at plasma membranes have long eluded researchers. Indeed, their identity as well as the mechanism of the PtdSer exposure to the cell surface has only recently been revealed. Here, we describe how PtdSer is exposed in apoptotic cells and in activated platelets, and discuss PtdSer exposure in other biological processes.

References

Jan 1, 1991·Physiological Reviews·E Carafoli
Mar 30, 1971·Biochemistry·R D Kornberg, H M McConnell
Dec 7, 1983·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M Seigneuret, P F Devaux
Nov 1, 1995·The Journal of Experimental Medicine·B VerhovenP Williamson
Apr 1, 1997·The EMBO Journal·R MarsaultR Rizzuto
Jan 12, 1999·The Journal of Physiology·J F Hussain, M P Mahaut-Smith
Oct 21, 1999·Experimental Cell Research·M KoteckiB H Cochran
Nov 13, 1999·Nature Cell Biology·T RichA Wyllie
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·A MünchauK P Bhatia
May 11, 2001·Nature·R S ScottG K Matsushima
Jul 4, 2001·Biochemistry·P WilliamsonE M Bevers
Jan 5, 2002·Annals of Neurology·A DanekA P Monaco
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sumie MannoNarla Mohandas
Dec 10, 2002·Annual Review of Physiology·Krishnakumar Balasubramanian, Alan J Schroit
Jul 29, 2003·European Journal of Immunology·Edward M BehrensPhilip L Cohen
Dec 4, 2003·Apoptosis : an International Journal on Programmed Cell Death·S M van den EijndeC Vermeij-Keers
May 5, 2004·American Journal of Human Genetics·Satoshi TsutsumiMitsuo Itakura
May 25, 2004·Science·Rikinari HanayamaShigekazu Nagata
Aug 11, 2004·The Journal of Experimental Medicine·Kenichi AsanoMasato Tanaka
May 28, 2005·Biochimica Et Biophysica Acta·C C Paulusma, R P J Oude Elferink
Jun 3, 2005·The Journal of Biological Chemistry·Sougata KarmakarRodger P McEver
Jul 19, 2005·Nature Cell Biology·James I ElliottChristopher F Higgins
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rikinari Hanayama, Shigekazu Nagata
Apr 22, 2006·Cell Death and Differentiation·D V KryskoP Vandenabeele

❮ Previous
Next ❯

Citations

May 27, 2016·Biochemistry·Kenji IshiharaShigekazu Nagata
Aug 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jun SuzukiShigekazu Nagata
Aug 30, 2016·International Journal of Molecular Sciences·Masatoshi MakiHideki Shibata
Oct 5, 2016·Critical Reviews in Biochemistry and Molecular Biology·Bartholomew P Roland, Todd R Graham
Jun 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sayuri GyobuShigekazu Nagata
Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mahiru Kawano, Shigekazu Nagata
Feb 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wenlei YeLily Yeh Jan
Mar 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Rikiya WatanabeShigekazu Nagata
Feb 6, 2018·Annual Review of Immunology·Shigekazu Nagata
Nov 22, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher D Gregory, Margaret Paterson
Apr 7, 2018·The British Journal of Dermatology·M ZhouY Jia
Jun 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mattia MalvezziAlessio Accardi
Aug 1, 2018·European Journal of Clinical Investigation·Fariborz MobarrezDavid S Pisetsky
Oct 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laila KarraFrancesca Levi-Schaffer
Oct 26, 2018·Proceedings of the National Academy of Sciences of the United States of America·Katsumori SegawaShigekazu Nagata
Mar 13, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Muxin YuJialan Shi
Dec 15, 2018·Journal of Neurochemistry·Yeming YangXianjun Zhu
Feb 21, 2019·ELife·Valeria KalienkovaCristina Paulino
Sep 24, 2016·Scientific Reports·Wataru NakaiRikinari Hanayama
Apr 14, 2019·Cardiovascular Research·Lucy McShanePasquale Maffia
Sep 19, 2018·Biomolecules·Hélène PolletDonatienne Tyteca
Oct 24, 2019·Immunology·Anna-Lena BollingerJörg Dieter Seebach
Dec 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuta RyodenShigekazu Nagata
Feb 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Habtamu B BeyenePeter J Meikle
Apr 15, 2020·Journal of Gastroenterology and Hepatology·Shuko IwataniTetsuo Takehara
Sep 25, 2019·Cold Spring Harbor Perspectives in Biology·Carla V Rothlin, Sourav Ghosh
May 16, 2020·Critical Reviews in Biochemistry and Molecular Biology·Hye-Won Shin, Hiroyuki Takatsu
Jun 20, 2018·The Journal of General Physiology·Maria E FalzoneAlessio Accardi
Jun 29, 2017·Scientific Reports·Kyong Nyon NamRadosveta Koldamova
Dec 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Christian W KellerJan D Lünemann
Feb 25, 2018·Nature Communications·Ilke S TuranEngin U Akkaya
Mar 9, 2018·Frontiers in Immunology·Angelo A ManfrediNorma Maugeri
May 11, 2018·Advanced Healthcare Materials·Heng ZhaoShiping Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Trends in Cell Biology
Katsumori Segawa, Shigekazu Nagata
Current Topics in Developmental Biology
Satoshi TodaShigekazu Nagata
Methods in Molecular Biology
Amelia E Hochreiter-HuffordKodi S Ravichandran
Advances in Experimental Medicine and Biology
Jason G Kay, Sergio Grinstein
© 2022 Meta ULC. All rights reserved