Exposure of piglet coronary arterial muscle cells to low alcohol results in elevation of intracellular free Ca2+: relevance to fetal alcohol syndrome

European Journal of Pharmacology
M B AlturaB M Altura

Abstract

Chronic exposure of cultured piglet neonatal coronary arterial smooth muscle cells to low concentrations of ethanol (46-115 mg/dl) for 7 days resulted in concentration-dependent elevation in intracellular free Ca2+ ions ([Ca2+i); these rises (22-56%) in [Ca2+]i were not reversible upon short-term exposure to normal, Ca2(+)-containing physiological salt solution. These findings help to provide a rational basis for why ethanol can result in the well-known fetal alcohol syndrome, including cardiac defects and in-utero death.

Citations

Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·T A GirardP E Wainwright
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·Betty Zimmerberg, Heather E Weston
Nov 26, 2009·Clinical and Experimental Pharmacology & Physiology·Helena C ParkingtonMarianne Tare
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·R A BrownJ Ren
Jul 7, 1998·Toxicology and Applied Pharmacology·W LiB M Altura
May 21, 1999·Sexual Abuse : a Journal of Research and Treatment·S Williams
Feb 16, 2013·Genetics and Molecular Biology·Wakana MominoLavínia Schüler-Faccini
Sep 5, 2018·Addiction Biology·Yohaan FernandesJohann K Eberhart
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