PMID: 2096382Nov 1, 1990

Exposure of rats to high concentrations of 1,1,1-trichloroethane and its effects on brain lipid and fatty acid composition

Pharmacology & Toxicology
T Kyrklund, K G Haglid


Exposure of rats to 1,1,1-trichloroethane (TRI) (1200 p.p.m.) for 30 days resulted in changes in the fatty acid pattern of the brain ethanolamine phosphoglyceride. A decrease was observed in stearic acid (18:0) and arachidonic acid (20:4), while the 22-carbon (n-3) fatty acids were increased. These changes in the fatty acid pattern were similar to that observed previously in the rat for another solvent, perchloroethylene, at a lower exposure concentration (320 p.p.m). Both these solvents are little metabolised and it seems that a common mechanism exists whereby these solvents alter the fatty acid pattern of brain phospholipid upon exposure. The relatively low uptake of TRI makes a high exposure level (1200 p.p.m.) necessary to attain a blood concentration high enough for the changes to appear.


Jan 15, 1979·International Archives of Occupational and Environmental Health·A C Monster
Dec 1, 1979·Toxicology and Applied Pharmacology·D G PeggP G Watanabe
May 1, 1985·Canadian Journal of Physiology and Pharmacology·M T ClandininE Zsigmond
Mar 1, 1985·Alcoholism, Clinical and Experimental Research·G Y Sun, A Y Sun
Jan 1, 1986·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·T KyrklundK G Haglid
Aug 1, 1987·Toxicology·T KyrklundK G Haglid
Jan 1, 1982·Toxicology and Applied Pharmacology·W T StottP G Watanabe

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