PMID: 8585515Aug 1, 1995Paper

Exposure-response analysis of mortality among coal miners in the United States

American Journal of Industrial Medicine
E D KuempelC R Buncher

Abstract

The quantitative relationship between exposure to respirable coal mine dust and mortality from nonmalignant respiratory diseases was investigated in a study of 8,878 working male coal miners who were medically examined from 1969 to 1971 and followed to 1979. Exposure-related mortality was evaluated using Cox proportional hazards modeling for underlying or contributing causes of death and modified lifetable methods for underlying causes. For pneumoconiosis mortality, the lifetable analyses showed increasing standardized mortality ratios (SMRs) with increasing cumulative exposure category. Significant exposure-response relationships for mortality from pneumoconiosis (p < 0.001) and from chronic bronchitis or emphysema (p < 0.05) were observed in the proportional hazards models after controlling for age and smoking. No exposure-related increases in lung cancer or stomach cancer were observed. Pneumoconiosis mortality was found to vary significantly by the rank of coal dust to which miners were exposed. Miners exposed at or below the current U.S. coal dust standard of 2 mg/m3 over a working lifetime, based on these analyses, have an elevated risk of dying from pneumoconiosis or from chronic bronchitis or emphysema.

References

Aug 13, 1977·British Medical Journal·D C MuirW H Walton
Apr 1, 1975·Chest·J CostelloW K Morgan
Aug 1, 1992·American Industrial Hygiene Association Journal·M D Attfield, K Morring
Apr 1, 1992·American Industrial Hygiene Association Journal·M D Attfield, K Morring
Nov 1, 1990·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·K SteenlandL Stayner
Oct 1, 1973·Archives of Environmental Health·W K MorganE P Shoub
Mar 1, 1974·American Journal of Public Health·J CostelloW K Morgan
Aug 1, 1974·Archives of Environmental Health·C E OrtmeyerM Peterson
Aug 1, 1969·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·W S Lainhart
Jan 23, 1982·British Medical Journal·D W Gau, A K Diehl

❮ Previous
Next ❯

Citations

Jun 1, 2001·American Journal of Industrial Medicine·I Szadkowska-Stańczyk, W Szymczak
Jan 8, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Xi Huang, Robert B Finkelman
Sep 20, 2005·Occupational and Environmental Medicine·V C dos S AntaoM D Attfield
Mar 3, 2007·Occupational and Environmental Medicine·Kanta SircarMichael Attfield
May 9, 2009·American Journal of Respiratory and Critical Care Medicine·Eileen D KuempelFrancis H Y Green
Apr 10, 2004·American Journal of Respiratory Cell and Molecular Biology·Mohamed M GhanemAnn F Hubbs
Aug 10, 2000·Environmental Health Perspectives·V Castranova, V Vallyathan
Sep 13, 2006·Environmental Health Perspectives·Mohamed M GhanemAnn F Hubbs
Aug 27, 2013·PloS One·Wiley D JenkinsK Thomas Robbins
Nov 17, 2012·Clinics in Chest Medicine·A Scott Laney, David N Weissman
Jul 16, 2011·American Journal of Industrial Medicine·Deborah D LandenAmi Patel
Oct 12, 2011·American Journal of Industrial Medicine·H Dean HosgoodQing Lan
Dec 13, 2005·Mutation Research·Lale DonbakMehmet Topaktas
Oct 21, 2015·International Archives of Occupational and Environmental Health·Matthias Möhner
May 9, 2014·Occupational and Environmental Medicine·Judith M GraberLorraine M Conroy
Nov 5, 2013·Occupational and Environmental Medicine·Judith M GraberMichael D Attfield
Apr 4, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jennifer L PerretAlastair Stewart
Mar 9, 2017·International Journal of Environmental Research and Public Health·Hana TomáškováZdeněk Jirák
Jan 7, 2003·Clinics in Chest Medicine·Robert Cohen, Valerie Velho
Feb 28, 2007·Toxicologic Pathology·Francis H Y GreenFletcher F Hahn
Jan 30, 2004·American Journal of Industrial Medicine·Michael D Attfield, Joseph Costello
Feb 6, 2008·American Journal of Industrial Medicine·M D Attfield, E D Kuempel
Feb 22, 2008·Environmental and Molecular Mutagenesis·Ozge Cemiloglu UlkerAsuman Karakaya
Nov 22, 2005·American Journal of Industrial Medicine·Timothy DriscollAnnette Prüss-Ustün
Oct 20, 2006·Critical Reviews in Toxicology·Thomas W HesterbergGeorgia A Hart
Aug 18, 2018·Annals of the American Thoracic Society·Kirsten S AlmbergRobert A Cohen
Mar 26, 2021·BioMed Research International·Linlin LiBaosen Zhou
Mar 30, 2021·Revue des maladies respiratoires·O LaraquiC H Laraqui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.