Dec 19, 2002

Exposure Risk in the Handling and Administration of Chemotherapy Agents: A Review and Synthesis of the Literature

The Online Journal of Knowledge Synthesis for Nursing
Mary Ann RitchieNancy Fritz


PURPOSE: This paper synthesizes research findings on known exposure risks to and compliance among health care professionals in the handling of neoplastic agents and suggests implications for practice and future research. CONCLUSIONS: The exposure risk for experiencing mutagenicity and alterations in fertility from chemotherapy agents among health care professionals has been extensively studied. Exposure risk and its relationship to health care professionals' compliance to established protocols for the safe handling and administration of chemotherapy agents continues to be a concern for health care institutions. Research in this area has been mainly retrospective and most studies have used a causal-comparative design; the degree of mutagenicity has been quantified for an identified exposed group and compared with a group that has not been exposed to antineoplastic agents. The evaluation of exposure has been found to be a complex problem because of the considerable mediating factors that are multifactorial and interactive in nature. Despite these confounding factors, the findings of past studies suggest that unsafe practice leads to an increased risk of exposure. IMPLICATIONS: Findings from existing research indicate that complia...Continue Reading

  • References21
  • Citations2


Mentioned in this Paper

Infertility Study
Antineoplastic Agents
Confounding Factors (Epidemiology)

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Head And Neck Squamous Cell Carcinoma

Squamous cell carcinomas account for >90% of all tumors in the head and neck region. Head and neck squamous cell carcinoma incidence has increased dramatically recently with little improvement in patient outcomes. Here is the latest research on this aggressive malignancy.

Signaling in Adult Neurogenesis

Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. Of interest is the role signalling mechanisms in adult neurogenesis. Discover the latest research on signalling in adult neurogenesis.

Psychiatric Chronotherapy

Psychiatric Chronotherapy considers the circadian rhythm as a major factor for optimizing therapeutic efficacy of psychiatric interventions. Discover the latest research on Psychiatric Chronotherapy here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Related Papers

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Nikola IvicićBerislav Momcilović
© 2020 Meta ULC. All rights reserved