Exposure time-dependent effects on the relative potencies and additivity of PAHs in the Ah receptor-based H4IIE-luc bioassay

Environmental Toxicology and Chemistry
Maria LarssonMagnus Engwall

Abstract

In the present study, relative potency factors (REPs) of 16 individual polycyclic aromatic hydrocarbons (PAHs) were investigated using the H4IIE-luc bioassay. Exposure time-dependent effects on the REPs were examined using 24, 48, and 72 h of exposure. Seven different mixtures of PAHs were tested for additivity at an exposure time of 24 h. Three of the PAH mixtures were also studied at 48 and 72 h of exposure. The mixture toxicities were predicted using the REP concept and the concentration addition (CA) model. Relative potency factor values investigated in the present study were similar to those reported in earlier studies. Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. The results from the mixture studies indicated that additive interactions of PAHs are time dependent. Generally, 48- and 72-h exposures resulted in biological effects that were similar to the CA and REP model predictions, while these models tended to underestimate the effect, to some extent, in the 24-h exposure, at least for the mixtures containing two...Continue Reading

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Citations

May 15, 2013·Environmental Science and Pollution Research International·Maria LarssonMagnus Engwall
Apr 30, 2015·Environmental Science & Technology·Ling JinBeate I Escher
Oct 8, 2015·Environmental Toxicology and Chemistry·Fenghua WeiXiaowei Zhang
Aug 19, 2016·Environmental Pollution·Honghong LyuJohn P Giesy
Feb 5, 2019·Environmental Science and Pollution Research International·Christine SchönlauAnna Kärrman
Nov 3, 2017·Archives of Toxicology·Mitra C GeierRobert L Tanguay
Oct 8, 2018·Archives of Toxicology·Constanze KnebelPhilip Marx-Stoelting
Nov 2, 2020·The Science of the Total Environment·Shangbo ZhouHenner Hollert
Jan 22, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yao ZhouToine F H Bovee
Jul 23, 2019·Environmental Science & Technology·Jaeseong KimJong Seong Khim

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