Exposure to 3,4-methylenedioxymethamphetamine (MDMA) on postnatal days 11-20 induces reference but not working memory deficits in the Morris water maze in rats: implications of prior learning

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Charles V VorheesMichael T Williams

Abstract

3,4-methylenedioxymethamphetamine (MDMA) in previous experiments has been shown to induce long-term spatial and sequential learning and memory deficits in adult offspring after exposure to the drug on postnatal (P) days 11-20, but not after exposure on P1-10. Herein we further tested for the effects of MDMA (0, 5, 10 or 20 mg/kg x 2/day) after exposure on P11-20 on reference and working memory in the Morris water maze (MWM), on reference memory in the Barnes maze, and on cued learning in the visible platform version of the MWM. The MWM and Barnes mazes were counterbalanced such that half the litters received the MWM-first and the other half received the Barnes maze first. Effects on MWM performance as a function of test order were observed. For animals that received the Barnes maze first, spatial MWM learning and memory trends were seen but they were not significantly different between MDMA groups and saline controls. For those receiving the MWM-first, there are consistent impairments on all measures in the MDMA groups compared to controls on MWM performance (latency, path length, and cumulative distance from the goal). On probe trials, MDMA animals receiving the MWM-first showed increased distance from the target site compared...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Jul 1, 1996·Reviews in the Neurosciences·D P Cain, D Saucier
Oct 30, 1999·Lancet·P R McElhattonS H Thomas
Jul 10, 2002·Annals of the New York Academy of Sciences·Jerrold S Meyer, Syed F Ali
Apr 25, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ratna Sircar

❮ Previous
Next ❯

Citations

May 15, 2012·ACS Chemical Neuroscience·Tori L SchaeferMichael T Williams
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Mar 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Frank O JohnsonRussell L Carr
Mar 12, 2008·Behavioural Pharmacology·Matthew R SkeltonCharles V Vorhees
Aug 22, 2012·Pediatrics·Lynn T SingerAndrew C Parrott
Nov 25, 2014·Toxicology Reports·Michael T WilliamsRussell W Brown
Jan 26, 2016·Neurotoxicology and Teratology·Lynn T SingerAndrew C Parrott
Mar 6, 2012·Neurotoxicology and Teratology·Lynn T SingerAndrew C Parrott
Dec 7, 2010·Physiology & Behavior·Jamshid FarajiRobert J Sutherland
Mar 5, 2016·Frontiers in Psychiatry·Jarid Goodman, Mark G Packard
Dec 19, 2006·Neurotoxicology and Teratology·Brian J Piper
Feb 11, 2014·BioMed Research International·Georg F WeberGary A Gudelsky
Feb 6, 2013·Pharmacology, Biochemistry, and Behavior·D N HarperM Hunt
May 6, 2015·European Journal of Pharmacology·Stuart A CollinsBryan K Yamamoto
Mar 5, 2011·Neurobiology of Learning and Memory·C KayM Hunt
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Matthew R SkeltonCharles V Vorhees
Jan 12, 2013·The International Journal of Neuropsychopharmacology·Tori L SchaeferCharles V Vorhees
Aug 20, 2014·Frontiers in Behavioral Neuroscience·Jamshid FarajiGerlinde A S Metz
Mar 3, 2006·Journal of Psychopharmacology·Neil Easton, Charles A Marsden
Jun 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily J RossGregg D Stanwood
Nov 25, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Kinga GawelJolanta H Kotlinska
Jul 14, 2021·Neurotoxicology and Teratology·Charles V Vorhees, Michael T Williams
Dec 23, 2009·Neuroscience Letters·Alejandra Arias-CavieresBernardo Morales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.