Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation

Toxicology
Jun KangMingqing Chen

Abstract

Several epidemiological and experimental studies indicate a positive association between exposure to formaldehyde or phthalates and allergic asthma. However, nothing is yet known about the effects of exposure to formaldehyde and phthalates together, nor the role of each on allergic asthma. Here, we investigated the effects of a combined exposure to formaldehyde and diisononyl phthalate (DINP) on asthma-like pathology in mice, and determined the underlying mechanisms implicated in NF-κB and ROS. Mice were exposed to formaldehyde and/or DINP and sensitization with OVA. The results showed that exposure to 1.0 mg/m3 formaldehyde or 20 mg/kg·d DINP slightly aggravated the airway wall remodeling, promoted the production of IgE and IgG1, and induced the occurrence of airway hyperresponsiveness (AHR). However, these pathological responses and AHR were greatly exacerbated by the combined exposure to formaldehyde and DINP. Administering melatonin to block oxidative stress, alleviated the pathological responses and AHR induced by formaldehyde and DINP, and inhibited the activation of the NF-κB and the secretion of TSLP. Blocking NF-κB with Dehydroxymethylepoxyquinimicin, inhibited the elevation of TSLP expression and Th2/Th17 cytokine sec...Continue Reading

Citations

Oct 31, 2020·Biology of Reproduction·Shuhong YangRomana A Nowak
Jan 8, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Qing ZhangYu Hong
Mar 27, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chongyao LiPing Ma
Mar 19, 2021·Allergy, Asthma & Immunology Research·Young Min KimKangmo Ahn
May 24, 2021·Environmental Science and Pollution Research International·Hamidreza Mohammadi, Sorour Ashari
Aug 20, 2019·Chemical Research in Toxicology·Ana K Gutiérrez-GarcíaAntonio De Leon-Rodriguez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2022 Meta ULC. All rights reserved