Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring

Frontiers in Behavioral Neuroscience
María Teresa Ramírez-LópezRaquel Gómez de Heras

Abstract

Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypothalamic contents of arachidonic acid and the two major endocannabinoids (anandamide and 2-arachidonoylglycerol) at birth. Palmitoylethanolamide, but not oleoylethanolamide, also decreased. Additionally, pups from palatable diet-fed dams displayed lower levels of anandamide and palmitoylethanolamide in the hippocampus. The low-weight male offspring, born from palatable diet exposed mothers, gained less weight during lactation and although they recovered weight during the post-weaning period, they developed abdominal adiposity in adulthood. These animals exhibite...Continue Reading

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Citations

Jan 2, 2019·Cellular and Molecular Life Sciences : CMLS·Inigo Ruiz de Azua, Beat Lutz
Apr 18, 2019·Reproductive Biology and Endocrinology : RB&E·Julian K ChristiansRaajan Garcha
Mar 29, 2019·Journal of Diabetes and Metabolic Disorders·Madeline Rose KeleherJames M Cheverud
Dec 15, 2020·Neuroscience and Biobehavioral Reviews·Jaume F Lalanza, Eelke M S Snoeren

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Software Mentioned

MAZEsoft
GraphPad Prism
GraphPad
SPSS15

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