Exposure to a Low Lead Concentration Impairs Contractile Machinery in Rat Cardiac Muscle

Biological Trace Element Research
Marito A S C SilvaEdna A Silveira

Abstract

Lead exposure has been considered to be a risk factor for hypertension and cardiovascular disease. Our purpose was to evaluate the effects of low plasma lead concentration on cardiac contractility in isolated papillary muscles. Wistar rats were divided in control group or group treated with 100 ppm of lead acetate in the drinking water for 15 days. Blood pressure (BP) was measured weekly. At the end of the treatment period, the animals were anesthetized and euthanized, and parameters related to isolated papillary muscle contractility were recorded. The lead concentrations in the blood reached 12.3 ± 2 μg/dL. The BP was increased in the group treated with 100 ppm of lead acetate. Lead treatment did not alter force and time derivatives of the force of left ventricular papillary muscles. In addition, the inotropic response induced by an increase in the extracellular Ca(2+) concentration was reduced in the Pb(2+) group. However, the uptake of Ca(2+) by the sarcoplasmic reticulum and the protein expression of SERCA and phospholamban remained unchanged. Postrest contraction was similar in the both groups, and tetanic peak and plateau tension were reduced in lead group. These results demonstrated that the reduction in the inotropic re...Continue Reading

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Citations

Nov 13, 2017·Cardiovascular Drugs and Therapy·Roy O MathewMandeep S Sidhu
Nov 9, 2018·The Journal of Toxicological Sciences·Liyun HeGaochun Zhu
Sep 22, 2019·Cardiovascular Toxicology·Chand Basha Davuljigari, Rajarami Reddy Gottipolu
Jan 16, 2021·International Journal of Environmental Research and Public Health·Laurie K SvobodaDana C Dolinoy
Feb 17, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rehab M ElgharabawyAmira S Ahmed
Apr 4, 2021·International Journal of Molecular Sciences·Svetlana V KlinovaYuri L Protsenko
Apr 12, 2021·Environmental Science and Pollution Research International·Zihan ChenXijin Xu
Aug 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Boris A KatsnelsonYuri L Protsenko
Sep 25, 2021·Environmental Health Perspectives·Lars LindMartyn T Smith

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