Exposure to a novel context following contextual fear conditioning enhances the induction of hippocampal long-term potentiation

The European Journal of Neuroscience
Helen Motanis, Mouna Maroun

Abstract

The prior behavioral experience of an animal can influence the direction and the probability of long-term plasticity induced at the activated synapses. In the present study, we compared alterations in long-term potentiation in the rat CA1 of the hippocampus following post-fear conditioning exposure to the conditioning context vs. a novel context. Furthermore, we examined whether the alterations in long-term potentiation are dependent on the prior formation of context-shock fear memory association. Whereas retrieval of fear memory 1 h after conditioning in the conditioning context was associated with impairment in the magnitude of long-term potentiation, exposure to a novel context at the same time point was associated with a robust increase in long-term potentiation. This effect was time-dependent, as exposure to a novel context 24 h after conditioning resulted in impaired long-term potentiation. Furthermore, preventing the formation of a fear context-shock association resulted in different modifications to long-term potentiation levels, regardless of whether association formation was prevented behaviorally (i.e. using a minimal context-shock association) or pharmacologically (using the N-methyl-d-aspartic acid receptor antagon...Continue Reading

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Citations

Jul 14, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rose-Marie Vouimba, Mouna Maroun
Jan 23, 2016·Psychoneuroendocrinology·Naama Brill-Maoz, Mouna Maroun
Apr 16, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walaa AwadMouna Maroun

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