Exposure to acrylamide and the risk of cardiovascular diseases in the National Health and Nutrition Examination Survey 2003-2006

Environment International
Yu ZhangYongning Wu

Abstract

Long-term exposure to acrylamide (AA) from diet sources may induce oxidative stress and chronic inflammation. However, the association between AA exposure and the prevalence of cardiovascular diseases (CVD) remains unclear. We aimed to examine the association between blood exposure levels of AA biomarkers and the prevalence of main types of CVD in a general population of US adults. We analyzed the associations between AA hemoglobin biomarkers [hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA), sum of HbAA and HbGA (HbAA+HbGA), and ratio of HbGA to HbAA (HbGA:HbAA)] and self-reported diagnosis of CVD in 8290 adults (≥20 years of age) from the National Health and Nutrition Examination Survey (NHANES) 2003-2006. Multivariable logistic regression models were employed for estimating the associations in three groups classified by the combination of smoking status and serum cotinine levels. In people exposed to environmental tobacco smoke (n = 4670), HbGA, HbAA+HbGA, and HbGA:HbAA were significantly and inversely associated with the prevalence of total CVD (p < 0.0001, p = 0.0155, and p = 0.0014 for trend, respectively) after adjusting for various covariates. The odd ratios (ORs) for total CVD in the highest quartiles of ...Continue Reading

Citations

Oct 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Gloria Hoi-Yee LiChing-Lung Cheung
Aug 15, 2020·The British Journal of Nutrition·G PagliaiF Sofi
May 31, 2019·BMJ : British Medical Journal·Bernard SrourMathilde Touvier
Nov 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Melissa M LaneTetyana Rocks
Oct 4, 2020·Ecotoxicology and Environmental Safety·Shengen LiaoXinli Li
Jul 30, 2021·Environmental Science and Pollution Research International·Guowei ZengKai-Hong Wu
Aug 20, 2021·Ecotoxicology and Environmental Safety·Li ZhuYu Zhang
Sep 4, 2021·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Shengjue XiaoDefeng Pan
Sep 30, 2021·Journal of Agricultural and Food Chemistry·Anli WangYu Zhang
Oct 14, 2021·Current Gastroenterology Reports·Osman Mohamed ElfadilManpreet S Mundi
Nov 10, 2021·Journal of Agricultural and Food Chemistry·Zhaoying LiDongfeng Zhang

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