Exposure to acrylamide decreases noradrenergic axons in rat brain.

Neurotoxicology
Lingyi ZhangGaku Ichihara

Abstract

Acrylamide is known to induce disorders in the central nervous system in humans and experimental animals. The present study investigated effects of exposure to acrylamide on adult neurogenesis, noradrenergic axons and the level of norepinephrine in the brain of male rats. Four groups of 12 male Wistar rats each were exposed to acrylamide at 0, 0.2, 2 and 20 mg/kg body weight by gavage for 5 weeks. Six rats of each groups were injected with 5-bromo-2'-deoxy-uridine (BrdU) after five-week exposure to acrylamide to examine proliferative cells in the dentate gyrus using immunostaining. Density of noradrenergic and serotonergic axons in the prefrontal cortex, hippocampus and cortex behind the bregma was quantified. Remaining 6 rats were decapitated after the last exposure and brains were dissected out to measure monoamine level in the hippocampus and prefrontal cortex using high performance liquid chromatography. Exposure to acrylamide dose-dependently decreased the density of noradrenergic axons in the prefrontal cortex with a significant change at 20 mg/kg. Norepinephrine level decreased in the hippocampus at 20 mg/kg. Exposure to acrylamide at 20 mg/kg or less did not change the number of BrdU positive cells, but the result shoul...Continue Reading

Citations

Mar 17, 2021·Environmental Science and Pollution Research International·Suzan Costa ZilliSiara Silvestri
Apr 20, 2021·Toxicology·Frederick Adams EkubanGaku Ichihara
Nov 10, 2021·Journal of Agricultural and Food Chemistry·Zhaoying LiDongfeng Zhang

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